Clone:
REA825
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
TP53, BCC7, LFS1, TRP53, NY-CO-13

Specifications for p53 pS15 Antibody, anti-human, REAfinity™

Overview

Clone REA825 recognizes the human cellular tumor antigen p53 phosphorylated at serine 15 (pS15). The p53 protein is an important regulator of cell growth and, thus, functions as a tumor suppressor in many tumor types. The p53 tumor suppressor gene is altered or deleted in most solid human tumors. It is tightly regulated and plays a critical role in the cellular response to environmental stress. Upon a cell's exposure to stress, such as hypoxia or genomic damage, the p53 protein is expressed at high levels and is post-translationally modified. These modifications, which include phosphorylation, acetylation, and glycosylation, occur rapidly and lead to the activation of p53, resulting in either G1 growth arrest or programmed cell death. Following DNA damage, p53 is phosphorylated on serine residues 15, 20, 33, and 37 within the amino-terminal domain. These phosphorylation events are thought to play a key role in regulating p53 stability and activity.
Additional information: Clone REA825 displays negligible binding to Fc receptors.

Alternative names

TP53, BCC7, LFS1, TRP53, NY-CO-13

Detailed product information

Technical specifications

CloneREA825
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
Antigenp53 pS15
Alternative names of antigenTP53, BCC7, LFS1, TRP53, NY-CO-13
Molecular mass of antigen [kDa]44
Distribution of antigentumor cells
Entrez Gene ID7157
RRIDAB_2653139, AB_2653140, AB_2653141, AB_2653138

Resources for p53 pS15 Antibody, anti-human, REAfinity™

Certificates

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References for p53 pS15 Antibody, anti-human, REAfinity™

Publications

  1. Zakut-Houri, R. et al. (1985) Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4(5): 1251-1255
  2. Lees-Miller, S. P. et al. (1992) Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol. Cell. Biol. 12(11): 5041-5049
  3. Li, D. W. et al. (2006) Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities. Oncogene 25(21): 3006-3022

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