Clone:
REA875
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
FC
Alternative names:
P2RX7, P2X7

Specifications for P2X7R Antibody, anti-mouse, REAfinity™

Overview

Clone REA875 recognizes the mouse P2X7R antigen, also known as P2RX7 or P2X7 (P2X purinoceptor 7), which is a receptor for ATP that acts as a ligand-gated ion channel. P2X7R is involved in different inflammatory, immune, neurologic, and musculoskeletal disorders and is able to modulate LPS-induced macrophage production of inflammatory mediators. P2X7R is found on cells of the immune system, e.g., mast cells, microglia, macrophages, T cells, and B cells, in uterine endometrium, retina, and in the central and peripheral nervous systems.
Additional information: Clone REA875 displays negligible binding to Fc receptors.

Alternative names

P2RX7, P2X7

Detailed product information

Technical specifications

CloneREA875
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenP2X7R
Alternative names of antigenP2RX7, P2X7
Molecular mass of antigen [kDa]68
Distribution of antigenmast cells, microglia, macrophages, T cells, B cells
Entrez Gene ID18439
RRIDAB_2726492, AB_2726563, AB_2726493, AB_2726564, AB_2726494, AB_2726561, AB_2726491, AB_2726562

Resources for P2X7R Antibody, anti-mouse, REAfinity™

Certificates

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References for P2X7R Antibody, anti-mouse, REAfinity™

Publications

  1. Chessell, I. P. et al. (1998) Cloning and functional characterisation of the mouse P2X7 receptor. FEBS Lett. 439(1-2): 26-30
  2. Kawano, A. et al. (2012) Involvement of P2X4 receptor in P2X7 receptor-dependent cell death of mouse macrophages. Biochem. Biophys. Res. Commun. 419(2): 374-380
  3. Alves, L. A. et al. (2014) The P2X7 receptor: shifting from a low- to a high-conductance channel - an enigmatic phenomenon? Biochim. Biophys. Acta 1838(10): 2578-2587
  4. Bartlett, R. et al. (2014) The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease. Pharmacol. Rev. 66(3): 638-675

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