Type of antibody:
Primary antibodies, Recombinant antibodies
recombinant human IgG1
Alternative names:
Oct3/4A, Oct-3A, Oct-4, OTF-3, OTF-4, POU5F1, NF-A3, MGC22487

Specifications for Oct3/4 Antibody, anti-human/mouse, REAfinity™


Clone REA622 recognizes the human and mouse octamer-binding transcription factor 3/4 (Oct3/4). Oct3/4 is a homeodomain transcription factor belonging to the POU transcription factor family and is also known as POU domain class 5 transcription factor 1 (POU5F1). Oct3/4 is critical for the maintenance of totipotency in primate blastomeres and for pluripotency of the inner cell mass of developing mammalian embryos. This critical role of Oct3/4 is maintained in embryonic stem cells, the developing germline, and germline tumors, such as seminomas and embryonic teratocarcinomas. When inducing pluripotency in differentiated cells, Oct3/4 appears to be an essential but not the only required transcription factor. Oct3/4 acts as a transcriptional activator of genes involved in maintenance of undifferentiated state and as a repressor of differentiation-specific genes.
Additional information: Clone REA622 displays negligible binding to Fc receptors.

Alternative names

Oct3/4A, Oct-3A, Oct-4, OTF-3, OTF-4, POU5F1, NF-A3, MGC22487

Detailed product information

Technical specifications

Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hosthuman cell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman, mouse
Alternative names of antigenOct3/4A, Oct-3A, Oct-4, OTF-3, OTF-4, POU5F1, NF-A3, MGC22487
Molecular mass of antigen [kDa]39, 38(separately shown for human and mouse/rat)
Distribution of antigenembryonic germ cells
Entrez Gene ID5460, 18999
RRIDAB_2784442, AB_2819472, AB_2819457, AB_2784443

Resources for Oct3/4 Antibody, anti-human/mouse, REAfinity™


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References for Oct3/4 Antibody, anti-human/mouse, REAfinity™


  1. Nakagawa, E. et al. (2012) The novel function of Oct3/4 in mouse tooth development. Histochem. Cell Biol. 137(3): 367-376
  2. Niwa, H. et al. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24(4): 372-376
  3. Wey, E. et al. (1994) A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues. Eur. J. Biochem. 220(3): 753-762

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