Clone:
REA481
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC, MICS, IF, IHC
Alternative names:
ABCC1, ABC29, ABCC, GS-X, MRP, MRP-1

Specifications for MRP1 Antibody, anti-human, REAfinity™

Overview

Clone REA481 recognizes an intracellular epitope of the human multidrug resistance–associated protein 1 (MRP1) antigen, a 190 kDa multi-pass membrane protein also known as ATP-binding cassette sub-family C member 1 (ABCC1) or leukotriene C(4) transporter. MRP1 was initially identified because of its ability to confer multidrug resistance in lung cancer cells. It plays a role in protecting certain tissues from xenobiotic insults and that it mediates the ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs, and other xenobiotics from the cytoplasm. MRP1 also plays a role in the cellular efflux of the reduced and oxidized forms of glutathione and thus contributes to the many physiological and pathophysiological processes influenced by these small peptides, including oxidative stress.
Additional information: Clone REA481 displays negligible binding to Fc receptors.

Alternative names

ABCC1, ABC29, ABCC, GS-X, MRP, MRP-1

Detailed product information

Technical specifications

CloneREA481
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody (I), human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Specieshuman
AntigenMRP1
Alternative names of antigenABCC1, ABC29, ABCC, GS-X, MRP, MRP-1
Molecular mass of antigen [kDa]172
Distribution of antigenubiquitous
Entrez Gene ID4363
RRIDAB_2652956, AB_2652957, AB_2652958, AB_2652959, AB_2652960, AB_2652955

Resources for MRP1 Antibody, anti-human, REAfinity™

Certificates

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References for MRP1 Antibody, anti-human, REAfinity™

Publications

  1. Cole, S. P. et al. (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258(5088): 1650-1654
  2. He, S. M. et al. (2011) Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1). Curr. Med. Chem. 18(3): 439-481
  3. Leslie, E. M. et al. (2005) Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol. Appl. Pharmacol. 204(3): 216-237

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