IL-13 stands for interleukin 13. Mouse IL-13 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Mouse IL-13

Overview

IL-13 stands for interleukin 13. Mouse IL-13 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IL-13 can be used for a variety of applications including:
  • Inhibition of monocyte and macrophage activation.
  • B cell activation.

Detailed product information

Background information

IL-13 is an immune regulatory cytokine produced primarily by activated Tʜ2 cells as well as mast cells and NK cells. Signaling through the IL-13 receptor activates the JAK/STAT and IRS-1/IRS-2 pathways. IL-13 has anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6, and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Although IL-13 is involved in the pathogenesis of airway diseases such as asthma, it also plays a protective role for the mucosa, via induction of matrix metalloproteinases (MMPs) and other anti-inflammatory effects. In addition, IL-13 plays an important role in the expulsion of gastrointestinal parasites.

Biological activity

  • Proliferation of human TF-1 cells
  • research grade: ≥ 2.5×
    10
    5
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Mouse IL-13

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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