G-CSF stands for granulocyte-colony stimulating factor. Mouse G-CSF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Specifications for Mouse G-CSF

Overview

G-CSF stands for granulocyte-colony stimulating factor. Mouse G-CSF is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse G-CSF can be used for a variety of applications, including:
  • Growth promotion and differentiation of cells of the neutrophil lineage.
  • Induction of colony formation of normal and leukemic bone marrow cells in soft agar cultures.

Detailed product information

Background information

Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor that affects proliferation and differentiation especially of progenitors of the neutrophil and granulocyte lineages. It is produced mainly by monocytes and macrophages and a variety of other cells like astrocytes, fibroblasts, and endothelial cells in response to specific stimulation, for instance by endotoxin, TNF-α, and IFN-γ. Furthermore, G-CSF enhances the survival and influences the immunological functions of mature neutrophils. Thus, in addition to its properties as a hematopoietic growth factor G-CSF also acts as a mediator of host defense against infections, and inflammatory response.

Biological activity

  • Proliferation of mouse M-NFS-60 cells
  • research grade: ≥ 2×
    10
    7
    U/mg

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Resources for Mouse G-CSF

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

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