Clone:
REAL1048
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
Microtubule-associated protein 2, MAP-2

Specifications for MAP2 Antibody, anti-human/mouse, REAdye_lease™

Overview

Clone REAL1048 is an antibody fragment derived from the full MAP2 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1048 recognizes MAP2 (Microtubule-associated protein 2) and belongs to the microtubule-associated family. The proteins are involved in microtubules assembly, an essential step in neuritogenisis. MAP2 is known to stabilize microtubules growth by crosslinking each other and with intermediate filaments. MAP2 is suspected of interacting with tubulin and is mainly expressed in neurons. It has been reported, that it is also detected in different cancers including melanoma and breast cancer. Four isoforms of MAP2 have been characterized, MAP2A; MAP2B; MAP2C and MAP2D. MAP2D is expressed by glia cells. The MAP2 isoforms are thought to be involved in microtubule assembly.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

Microtubule-associated protein 2, MAP-2

Detailed product information

Technical specifications

CloneREAL1048
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman, mouse
AntigenMAP2
Alternative names of antigenMicrotubule-associated protein 2, MAP-2
Distribution of antigenneural cells, tumor cells, brain

References for MAP2 Antibody, anti-human/mouse, REAdye_lease™

Publications

  1. Goedert, M. et al. (1991) Molecular characterization of microtubule-associated proteins tau and MAP2. Trends Neurosci. 14(5): 193-199
  2. Soltani, M. H. et al. (2005) Microtubule-associated protein 2, a marker of neuronal differentiation, induces mitotic defects, inhibits growth of melanoma cells, and predicts metastatic potential of cutaneous melanoma. Am. J. Pathol. 166(6): 1841-1850
  3. Dehmelt, L. et al. (2005) The MAP2/Tau family of microtubule-associated proteins. Genome Biol. 6(1): 204-204
  4. Cabrera, J. R. et al. (2017) MAP2 Splicing is Altered in Huntington's Disease. Brain Pathol. 27(2): 181-189

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