IL-4 Secretion Assay – Detection Kit (PE), human

IL-4 Secretion Assay – Detection Kit (PE), human

The IL-4 Secretion Assay was developed for the sensitive detection of human IL-4-secreting cells.

Background information

Interleukin-4 (IL-4) is predominantly secreted by activated CD4
+
memory and effector T
H
2 cells, basophils, and mast cells. It induces and supports humoral immune responses for the neutralization of extracellular pathogens. The T
H
2 types of immune mechanisms can also be involved in immunologic disorders, such as IgE-mediated allergy. The IL-4 Secretion Assay (PE) can also be used for two-color cytokine analysis in combination with the IFN-γ Secretion Assay - Detection Kit (FITC) or the IFN-γ, IL-2, or IL-10 Secretion Assay - Detection Kits (APC).

Downstream applications

IL-4 Secretion Assays were used to isolate and analyze Tetanus Toxoid-specific
1
, allergen-specific
2,5
, and autoreactive
7
T cells from PBMCs, as well as tumor-specific cells from T cell lines
3
.
The IL-4 Secretion Assay was also used for isolation of IL-4-secreting human NK cells
4
, and for detection of IL-4-secreting NKT cells
6
.
IL-4-secreting CD8
+
T cells were isolated in combination with CD8 MultiSort MicroBeads.
8
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Product information

Size
Order no.
Price

IL-4 Secretion Assay – Detection Kit (PE), human

  • For research use only
for 100
tests
(1)
130-054-102
EUR 580,00 

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