REAlease® CD94 Complexes, human

REAlease
®
CD94 Complexes
, human

Clone: REAL287 | Dilution: 1:50
Clone REAL287 is an antibody fragment derived from the full CD94 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL287 recognizes CD94, an approximately 45 kDa, single-pass, type II transmembrane protein, which belongs to C-type lectin superfamily. CD94 associates covalently with NKG2 family members and forms disulfide bonded heterodimers. CD94-NKG2 receptors bind HLA-E, the non-classical MHC class Ib molecule. Depending on the associated NKG2 member, CD94-NKG2 heterodimer transmits either activating or inhibitory signal. For, e.g, via immunoreceptor tyrosine based-inhibitory motifs (ITIMs) containing NKG2A, CD94-NKG2A heterodimers inhibit NK cell cytotoxicity. Besides NK cells, expression of CD94-NKG2 heterodimers is also shown on NK-T cells and a small percentage of CD8 cells in mice, where the crosslinking of CD94-NKG2 was shown to reduce the level of spontaneous apoptosis.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative Names

KLRD1, Kp43

Technical specifications

  • Antigen: CD94
  • Clone: REAL287
  • Isotype control: REAL Control
  • Alternative names of antigen: KLRD1, Kp43
  • Distribution of antigen: NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC
Product options: 4

Product information

Size
Order no.
Price

REAlease CD94-FITC, human

  • REAL287
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-331
EUR 105,00 

REAlease CD94-FITC, human

  • REAL287
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-231
EUR 255,00 

REAlease CD94-APC, human

  • REAL287
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-327
EUR 125,00 

REAlease CD94-APC, human

  • REAL287
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-225
EUR 305,00 

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