REAlease® CD366 (TIM-3) Complexes, human

REAlease
®
CD366 (TIM-3) Complexes
, human

Clone: REAL226 | Dilution: 1:50
Clone REAL226 is an antibody fragment derived from the full CD366 (TIM-3) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL226 recognizes the human CD366 antigen, a single-pass type I membrane protein which is also known as T cell immunoglobulin and mucin domain containing protein-3 (TIM-3) or Hepatitis A virus cellular receptor 2 (HAVcr-2). CD366 is expressed on activated T cells, especially Tʜ1 cells, monocytes, macrophages, and dendritic cells. It is an activation-induced inhibitory molecule involved in tolerance and shown to induce T cell exhaustion in chronic viral infection and cancers. CD366 has been proposed to inhibit Tʜ1-mediated immune responses and regulates Tʜ1 and Tʜ17 cytokine secretion. The interaction of CD366 and its ligand galectin-9 induces apoptosis of Tʜ1 cells.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative Names

HAVcr-2, TIMD-3

Technical specifications

  • Antigen: CD366 (TIM-3)
  • Clone: REAL226
  • Isotype control: REAL Control
  • Alternative names of antigen: HAVcr-2, TIMD-3
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: dendritic cells, macrophages, monocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
Product options: 2

Product information

Size
Order no.
Price

REAlease CD366 (TIM-3)-PE, human

  • REAL226
  • 1:50
  • For research use only
for 30
tests
(1)
130-118-660
EUR 125,00 

REAlease CD366 (TIM-3)-PE, human

  • REAL226
  • 1:50
  • For research use only
for 100
tests
(1)
130-118-525
EUR 305,00 

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