CD96 (TACTILE) antibodies, human

CD96 (TACTILE) antibodies, human

Clone: REA195 | Dilution: 1:11
Clone REA195 recognizes CD96, which is also known as T cell–activated increased late expression (TACTILE). CD96 is a single-pass transmembrane glycoprotein belonging to the Ig superfamily and consists of three extracellular Ig-like domains and a membrane proximal region rich in proline/serine/threonine. Expression of CD96 is found on T cells, NK cells, and on majority of CD34
+
CD38
-
acute myeloid leukemic (AML) cells. CD96 interacts with CD155, which is also known as polio virus receptor and promotes NK cell adhesion to target cells expressing CD155. CD96 is further described as a tumor marker for T cell–acute lymphoblastic leukemia (T-ALL) and AML.
Additional information: Clone REA195 displays negligible binding to Fc receptors.

Alternative Names

TACTILE

Technical specifications

  • Antigen: CD96 (TACTILE)
  • Clone: REA195
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TACTILE
  • Distribution of antigen: T cells, NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin

REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the other known clones. 

Other clonesOverlap in epitope recognition with REA195
NK92.39++
  • Selected References

    1. Fuchs, A. et al. (2004) Cutting Edge: CD96 (Tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155). J. Immunol. 172: 3994-3998
    2. Meyer, D. et al. (2009) CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains. J. Biol. Chem. 284: 2235-2244
Product options: 4

Product information

Size
Order no.
Price

CD96 (TACTILE)-PE, human

  • REA195
  • 1:11
  • For research use only
for 30
tests
(1)
130-101-036
EUR 91,00 

CD96 (TACTILE)-PE, human

  • REA195
  • 1:11
  • For research use only
for 100
tests
(1)
130-101-032
EUR 236,00 

CD96 (TACTILE)-Biotin, human

  • REA195
  • 1:11
  • For research use only
for 30
tests
(1)
130-111-923
EUR 86,00 

CD96 (TACTILE)-Biotin, human

  • REA195
  • 1:11
  • For research use only
for 100
tests
(1)
130-111-751
EUR 252,00