CD95 (FAS) antibodies, human

CD95 (FAS) antibodies, human

Clone: DX2 | Dilution: 1:11
CD95, also known as FAS or Apo-1, is a member of the tumor necrosis factor receptor superfamily (TNFR) and is found on the surface of many normal and neoplastically transformed cells. Its ligand, CD95L (FASL/Apo-1L), is able to induce apoptosis in CD95-expressing cells upon binding. CD95 and CD95L are up-regulated on lymphocytes upon activation and are known to play a key role in the regulation of an inflammatory response: Juxtocrine “fratricide” of neighbouring lymphocytes via mutual CD95 and CD95L expression helps to terminate immune responses, while apoptosis of pro-inflammatory cells via CD95 helps maintain immune privilege in sites such as the eye, where CD95L is found to be expressed in the retina and cornea. Cross-linking of CD95 receptors by DX2 monoclonal antibody has been described to induce apoptosis in certain target cells.

Alternative Names

FAS, ALPS1A, APO-1, Apt1, FAS1, FASTM, Tnfrsf6

Technical specifications

  • Antigen: CD95 (FAS)
  • Clone: DX2
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: FAS, ALPS1A, APO-1, Apt1, FAS1, FASTM, Tnfrsf6
  • Entrez Gene ID: 355
  • Molecular mass of antigen [kDa]: 35
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: B cells, epithelial cells, fibroblasts, heart, kidney, liver, lung, monocytes, neutrophils, ovary, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, PE-Vio770, Biotin
Product options: 7

Product information

Size
Order no.
Price

CD95 (FAS)-FITC, human

  • DX2
  • 1:11
  • For research use only
for 30
tests
(1)
130-100-409
EUR 74,00 

CD95 (FAS)-FITC, human

  • DX2
  • 1:11
  • For research use only
for 100
tests
(1)
130-092-415
EUR 187,00 

CD95 (FAS)-PE, human

  • DX2
  • 1:11
  • For research use only
for 30
tests
(1)
130-099-094
EUR 91,00 

CD95 (FAS)-PE, human

  • DX2
  • 1:11
  • For research use only
for 100
tests
(1)
130-092-416
EUR 240,00 

CD95 (FAS)-PE-Vio770, human

  • DX2
  • 1:11
  • For research use only
for 30
tests
(1)
130-104-232
EUR 144,00 

CD95 (FAS)-PE-Vio770, human

  • DX2
  • 1:11
  • For research use only
for 100
tests
(1)
130-104-199
EUR 317,00 

CD95 (FAS)-Biotin, human

  • DX2
  • 1:11
  • For research use only
for 100
tests
(1)
130-092-418
EUR 240,00 

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