CD88 (C5AR) antibodies, human

CD88 (C5AR) antibodies, human

Clone: S5/1 | Dilution: 1:11
Clone S5/1 recognizes the human CD88 antigen, a 43 kDa G type protein–coupled receptor with seven membrane-spanning regions which is also known as C5a anaphylatoxin chemotactic receptor 1 (C5AR). CD88 expression is originally described on neutrophils and monocyte/macrophages, but it is also found on hepatocytes, epithelial cells, endothelial cells, tissue mast cells, and human fetal astrocytes. Constitutive CD88 expression was also detected on astrocytes, microglia, and fibroblast-like cells but not by oligodendrocytes. CD88 is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. It stimulates chemotaxis, granule enzyme release, and superoxide anion production. Sulfation plays a critical role in the association of CD88 with C5a, but no significant role in the ability of CD88 to transduce a signal and mobilize calcium in response to a small peptide agonist.

Alternative names

C5AR1, C5A, C5AR, C5R1

Technical specifications

  • Antigen: CD88 (C5AR)
  • Clone: S5/1
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: C5AR1, C5A, C5AR, C5R1
  • Entrez Gene ID: 728
  • Molecular mass of antigen [kDa]: 39
  • Distribution of antigen: neutrophils, monocytes, macrophages, endothelial cells, epithelial cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Gerard, N. P. et al. (1991) The chemotactic receptor for human C5a anaphylatoxin. Nature 349(6310): 614-617
    2. Farzan, M. et al. (2001) Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor. J. Exp. Med. 193(9): 1059-1066
    3. Buck, E. et al. (2005) Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor. Proc. Natl. Acad. Sci. U.S.A. 102: 2719-2724
Product options: 14
130-104-333

CD88 (C5AR)-FITC, human

for 30
tests
(1)
EUR 90,00 
130-104-284

CD88 (C5AR)-FITC, human

for 100
tests
(1)
EUR 220,00 
130-104-334

CD88 (C5AR)-PE, human

for 30
tests
(1)
EUR 110,00 
130-104-285

CD88 (C5AR)-PE, human

for 100
tests
(1)
EUR 265,00 
130-104-335

CD88 (C5AR)-APC, human

for 30
tests
(1)
EUR 110,00 
130-104-286

CD88 (C5AR)-APC, human

for 100
tests
(1)
EUR 265,00 
130-104-336

CD88 (C5AR)-PE-Vio770, human

for 30
tests
(1)
EUR 120,00 
130-104-287

CD88 (C5AR)-PE-Vio770, human

for 100
tests
(1)
EUR 290,00 
130-104-337

CD88 (C5AR)-APC-Vio770, human

for 30
tests
(1)
EUR 120,00 
130-104-288

CD88 (C5AR)-APC-Vio770, human

for 100
tests
(1)
EUR 290,00 
130-104-338

CD88 (C5AR)-PerCP-Vio700, human

for 30
tests
(1)
EUR 120,00 
130-104-289

CD88 (C5AR)-PerCP-Vio700, human

for 100
tests
(1)
EUR 290,00 
130-104-332

CD88 (C5AR)-Biotin, human

for 30
tests
(1)
EUR 90,00 
130-104-283

CD88 (C5AR)-Biotin, human

for 100
tests
(1)
EUR 220,00 

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