CD85j (ILT2) antibodies, human

CD85j (ILT2) antibodies, human

Clone: REA998 | Dilution: 1:50
Clone REA998 recognizes the human CD85j (ILT2) antigen, an inhibitory immunoreceptor of the immunoglobulin-like transcript (ILT) family. CD85j is a type I transmembrane protein with four extracellular Ig-like domains and four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail. The inhibitory signal is transmitted by recruiting SH2-containing protein tyrosine phosphatase-1 that dephosphorylates and inactivates downstream tyrosine kinases. Expression of CD85j is found on B cells, monocytes, dendritic cells, and subsets of natural killer (NK) and T cells. CD85j is known to bind classical and non-classical MHC class I molecules, human cytomegalovirus UL18 protein, and some HLA-C alleles, as ligands. Crosslinking of CD85j prevents activation of B cells, T cells, NK cells, macrophages, and downregulation of effector mechanisms, such as NK and T cells cytolytic functions.
Additional information: Clone REA998 displays negligible binding to Fc receptors.

Alternative Names

LILRB1, ILT2, LIR-1, MIR-7

Technical specifications

  • Antigen: CD85j (ILT2)
  • Clone: REA998
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LILRB1, ILT2, LIR-1, MIR-7
  • Entrez Gene ID: 10859
  • Molecular mass of antigen [kDa]: 68
  • Distribution of antigen: B cells, dendritic cells, lymphocytes, monocytes, NK cells, T cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, Biotin
Product options: 10

Product information

Size
Order no.
Price

CD85j (ILT2)-FITC, human

  • REA998
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-735
EUR 86,00 

CD85j (ILT2)-FITC, human

  • REA998
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-614
EUR 252,00 

CD85j (ILT2)-PE, human

  • REA998
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-736
EUR 112,00 

CD85j (ILT2)-PE, human

  • REA998
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-615
EUR 296,00 

CD85j (ILT2)-APC, human

  • REA998
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-737
EUR 146,00 

CD85j (ILT2)-APC, human

  • REA998
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-616
EUR 322,00 

CD85j (ILT2)-PE-Vio615, human

  • REA998
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-739
EUR 146,00 

CD85j (ILT2)-PE-Vio615, human

  • REA998
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-618
EUR 322,00 

CD85j (ILT2)-Biotin, human

  • REA998
  • 1:50
  • For research use only
for 30
tests
(1)
130-116-744
EUR 86,00 

CD85j (ILT2)-Biotin, human

  • REA998
  • 1:50
  • For research use only
for 100
tests
(1)
130-116-623
EUR 252,00 

Related products

3 products available