CD79b antibodies, mouse

CD79b antibodies, mouse

Clone: REA1117 | Dilution: 1:50
Clone REA1117 recognizes the mouse CD79b antigen, a 35–40kD single-pass type I membrane protein also known as B cell antigen receptor complex-associated protein beta chain (Igβ chain). The heterodimeric CD79 molecule is composed of an α chain (CD79a) and a β chain (CD79b) and is associated with surface immunoglobulins to form the B cell receptor. The CD79a/CD79b heterodimer facilitates the differentiation of pre–B cells from pro–B cells, surface expression of surface Ig, signal transduction following antigen recognition, and endocytosis of recognized antigens. Crosslinking of CD79b
in vitro
by monoclonal antibodies activates pre–B cells but blocks terminal differentiation of all plasma cell isotypes. It was shown that a combination of CD79a and CD79b monoclonal antibodies can effectively deplete B cells from peripheral blood, spleen, bone marrow, and lymph nodes in mice.
Additional information: Clone REA1117 displays negligible binding to Fc receptors.

Alternative Names

Ig-beta, B29, Igb

Technical specifications

  • Antigen: CD79b
  • Clone: REA1117
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Ig-beta, B29, Igb
  • Entrez Gene ID: 15985
  • Molecular mass of antigen [kDa]: 23
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770
  • Selected References

    1. Lin, J. and Justement, L. B. (1992) The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases. J. Immunol. 149: 1548-1555
    2. O'Neill, S. K. et al. (2011) Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity 35(5): 746-756
    3. Li, Y. et al. (2008) B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J. Immunol. 181(5): 2961-2972
Product options: 6
130-119-425

CD79b-PE, mouse

30 µg in 200 µL (1)
EUR 80,00 
130-119-325

CD79b-PE, mouse

150 µg in 1 mL (1)
EUR 230,00 
130-119-426

CD79b-APC, mouse

30 µg in 200 µL (1)
EUR 80,00 
130-119-326

CD79b-APC, mouse

150 µg in 1 mL (1)
EUR 230,00 
130-119-428

CD79b-PE-Vio770, mouse

30 µg in 200 µL (1)
EUR 100,00 
130-119-429

CD79b-APC-Vio770, mouse

30 µg in 200 µL (1)
EUR 100,00