CD7 antibodies, human

CD7 antibodies, human

Clone: CD7-6B7 | Dilution: 1:11
Clone CD7-6B7 recognizes the human CD7 antigen, a single-pass type I membrane protein, also known as leu-9 or GP40. CD7 appears early in T cell ontogeny and is expressed by most T cells in the periphery. It is also found on NK cells, hematopoietic progenitors, monocytes, acute lymphocytic leukemia, and some acute myeloid leukemia cells. Although the ligand is yet not identified, CD7 has been recognized as a co-stimulatory molecule. CD7 activates phosphatidylinositol 3-kinase which is involved in CD7-mediated regulation of integrin adhesiveness. Furthermore, it has been reported that the β-galactoside-binding lectin galectin-1 binds CD7, leading to induction of apoptosis of thymocytes and T cells, with implications for certain autoimmune diseases and T cell lymphomas.

Alternative Names

GP40, Leu-9, TP41, Tp40

Technical specifications

  • Antigen: CD7
  • Clone: CD7-6B7
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: GP40, Leu-9, TP41, Tp40
  • Entrez Gene ID: 924
  • Molecular mass of antigen [kDa]: 23
  • Distribution of antigen: T cells, NK cells, monocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, VioBlue, PE-Vio770, Biotin
  • Selected References

    1. Gallacher, L. et al. (2000)
      Isolation and characterization of human CD34
      Lin
      and CD34
      +
      Lin
      hematopoietic stem cells using cell surface markers AC133 and CD7.
      Blood 95(ARVO Annual Meeting Abstract): 2813-2820
    2. Aruffo, A. et al. (1987) Molecular cloning of two CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system. EMBO J. 6(11): 3313-3316
    3. Kobayashi, S. et al. (2013) The CD3 versus CD7 plot in multicolor flow cytometry reflects progression of disease stage in patients infected with HTLV-I. PLoS One 8(1): e53728
Product options: 12

Product information

Size
Order no.
Price

CD7-VioBright FITC, human

  • CD7-6B7
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-903
EUR 120,00 

CD7-VioBright FITC, human

  • CD7-6B7
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-844
EUR 290,00 

CD7-PE, human

  • CD7-6B7
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-899
EUR 110,00 

CD7-PE, human

  • CD7-6B7
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-840
EUR 265,00 

CD7-APC, human

  • CD7-6B7
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-900
EUR 110,00 

CD7-APC, human

  • CD7-6B7
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-841
EUR 265,00 

CD7-VioBlue, human

  • CD7-6B7
  • 1:11
  • For research use only
for 30
tests
(1)
130-106-508
EUR 115,00 

CD7-VioBlue, human

  • CD7-6B7
  • 1:11
  • For research use only
for 100
tests
(1)
130-106-459
EUR 275,00 

CD7-PE-Vio770, human

  • CD7-6B7
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-901
EUR 120,00 

CD7-PE-Vio770, human

  • CD7-6B7
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-842
EUR 290,00 

CD7-Biotin, human

  • CD7-6B7
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-898
EUR 90,00 

CD7-Biotin, human

  • CD7-6B7
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-839
EUR 220,00