CD69 antibodies, mouse

CD69 antibodies, mouse

Clone: REA937 | Dilution: 1:50
Clone REA937 recognizes the mouse CD69 antigen, a type II integral membrane protein with a C-type lectin domain. CD69 is expressed as a homodimer composed of heavily glycosylated subunits. It is rapidly induced upon activation of T and B cells, neutrophils, and NK cells, which is why CD69 has been mostly regarded as an activation marker. The precise role of CD69 in immunity has not been determined because its ligand is unknown. Freshly prepared thymocytes undergoing selection events express CD69, and regulatory roles for CD69 expression in T cell development in the thymus have been suggested. However, phenotypical analysis in previous studies using CD69-deficient mice has revealed that CD69 does not appear to be required for the development of CD4 T cells. CD69 is also expressed on platelets. Recent studies have shown that CD69 is constitutively expressed by tissue-resident Tʜ memory cells and that its function is essential for the generation of professional resting memory Tʜ cells.
Additional information: Clone REA937 displays negligible binding to Fc receptors.

Alternative names

AIM, VEA, EA1, MLR3, gp34/28

Technical specifications

  • Antigen: CD69
  • Clone: REA937
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: AIM, VEA, EA1, MLR3, gp34/28
  • Entrez Gene ID: 12515
  • Molecular mass of antigen [kDa]: 22
  • Distribution of antigen: B cells, granulocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770
  • Selected references

    1. Sancho, D. et al. (2005) CD69 is an immunoregulatory molecule induced following activation. Trends Immunol. 26(3): 136-140
    2. Shinoda, K. et al. (2012) Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc. Natl. Acad. Sci. U.S.A. 109(19): 7409-7414
    3. Sathaliyawala, T. et al. (2013) Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity 38(1): 187-197
Product options: 8
130-115-574

CD69-FITC, mouse

30 µg in 200 µL (1)
EUR 40,00 
130-115-459

CD69-FITC, mouse

150 µg in 1 mL (1)
EUR 120,00 
130-115-575

CD69-PE, mouse

30 µg in 200 µL (1)
EUR 80,00 
130-115-460

CD69-PE, mouse

150 µg in 1 mL (1)
EUR 230,00 
130-115-576

CD69-APC, mouse

30 µg in 200 µL (1)
EUR 80,00 
130-115-461

CD69-APC, mouse

150 µg in 1 mL (1)
EUR 230,00 
30 µg in 200 µL (1)
EUR 100,00 
30 µg in 200 µL (1)
EUR 100,00 

Related products

2 products available