CD63 antibodies, mouse

CD63 antibodies, mouse

Clone: REA563 | Dilution: 1:10
Clone REA563 recogizes the mouse CD63 antigen. It belongs to the tetraspanin transmembrane 4 superfamily (TM4SF) of proteins, which are characterized by four membrane spanning domains. Tetraspanins, via various homotypic and heterotypic interactions, regulate the spatial location and trafficking of associated transmembrane partners, eventually regulating and co-ordinating various signaling pathways. Interaction of CD63 with other membrane proteins or adaptors regulates cell activities such as adhesion, migration, and degranulation. CD63 is expressed on monocytes, macrophages, endothelium, fibroblasts, osteoclasts, smooth muscle cells, and activated platelets.
Additional information: Clone REA563 displays negligible binding to Fc receptors

Alternative names

ME491, Tspan30

Technical specifications

  • Antigen: CD63
  • Clone: REA563
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: ME491, Tspan30
  • Entrez Gene ID: 12512
  • Molecular mass of antigen [kDa]: 26
  • Distribution of antigen: monocytes, macrophages, endothelial cells, fibroblasts, osteoblasts, smooth muscle, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC-Vio770, Biotin, VioBright FITC, PE, APC
  • Selected references

    1. Miyamoto, H. et al. (1994) Molecular cloning of the murine homologue of CD63/ME491 and detection of its strong expression in the kidney and activated macrophages. Biochim. Biophys. Acta 1217(3): 312-316
    2. Doyle, E. L. et al. (2011) CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin. Blood 118(15): 4265-4273
    3. Kraft, S. et al. (2013) The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis. J. Immunol. 191(6): 2871-2878
Product options: 10
130-108-927

CD63-VioBright FITC, mouse

9 µg in 300 µL (1)
EUR 55,00 
130-108-897

CD63-VioBright FITC, mouse

30 µg in 1 mL (1)
EUR 100,00 
130-108-923

CD63-PE, mouse

9 µg in 300 µL (1)
EUR 39,00 
130-108-893

CD63-PE, mouse

30 µg in 1 mL (1)
EUR 80,00 
130-108-924

CD63-APC, mouse

9 µg in 300 µL (1)
EUR 55,00 
130-108-894

CD63-APC, mouse

30 µg in 1 mL (1)
EUR 80,00 
130-108-926

CD63-APC-Vio770, mouse

9 µg in 300 µL (1)
EUR 71,00 
130-108-896

CD63-APC-Vio770, mouse

30 µg in 1 mL (1)
EUR 100,00 
130-108-922

CD63-Biotin, mouse

9 µg in 300 µL (1)
EUR 20,00 
130-108-892

CD63-Biotin, mouse

30 µg in 1 mL (1)
EUR 40,00 

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