CD49c antibodies, human

CD49c antibodies, human

Clone: REA360 | Dilution: 1:11
Clone REA360 recognizes the human CD49c antigen, a single-pass type I membrane protein also known as integrin α-3 (ITGA3) or VLA-3α. CD49c forms a heterodimer with integrin β1 (α3β1, CD49c/CD29, VLA-3) and plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin. It is expressed by many types of adhesion cells, such as endothelial cells, epithelial cells, and dermal fibroblasts. Weak expression has been reported on leukocytes. CD49c/CD29 plays a role in cell-cell and cell-matrix adhesion through binding fibronectin, laminin, collagen, epiligrin, thrombospondin, and CSPG4.
Additional information: Clone REA360 displays negligible binding to Fc receptors.

Alternative names

ITGA3, MSK18, FRP-2, GAP-B3, GAPB3, ILNEB, VCA-2, VL3A, VLA-3α

Technical specifications

  • Antigen: CD49c
  • Clone: REA360
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ITGA3, MSK18, FRP-2, GAP-B3, GAPB3, ILNEB, VCA-2, VL3A, VLA-3α
  • Entrez Gene ID: 3675
  • Molecular mass of antigen [kDa]: 113
  • Distribution of antigen: epithelial cells, fibroblasts, leukocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Carter, W. G. et al. (1991) Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes. Cell 65(4): 599-610
    2. Takada, Y. et al. (1991) Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen. J. Cell Biol. 115(1): 257-266
    3. de Melker, A. A. et al. (1997) The A and B variants of the alpha 3 integrin subunit: tissue distribution and functional characterization. Lab. Invest. 76(4): 547-563
Product options: 14
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 
130-105-407

CD49c-APC, human

for 30
tests
(1)
EUR 110,00 
130-105-366

CD49c-APC, human

for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 275,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 

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