CD49a antibodies, mouse and rat

CD49a antibodies, mouse and rat

Clone: REA493 | Dilution: 1:10
Clone REA493 recognizes the mouse and rat CD49a antigen, a 180 kDa single-pass type I membrane protein also known as integrin α1 (Itga1). CD49a binds to CD29 (integrin β1) to form the heterodimeric integrin very late antigen 1 (VLA-1), which has been found to be widely expressed on various cell types, including mesenchymal cells, epithelial cells, macrophages, NKT cells, and T cells. VLA-1 is a receptor for laminin and collagen and interacts, via the I-domain of the extracellular domain of the CD49a subunit, with collagen molecules in the extracellular matrix. CD49a expression parallels high levels of IFN-γ production in effector T cells, and CD49a has been intensively studied for its role in mediating T-cell accumulation, apoptosis, and retention within pathological tissues in immune-mediated inflammation.
Additional information: Clone REA493 displays negligible binding to Fc receptors.

Alternative names

Itga1, VLA-1

Technical specifications

  • Antigen: CD49a
  • Clone: REA493
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Itga1, VLA-1
  • Entrez Gene ID: 25118, 109700
  • Molecular mass of antigen [kDa]: 128
  • Distribution of antigen: macrophages, T cells, epithelial cells, NKT cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Ben-Horin, S. et al. (2004) The role of very late antigen-1 in immune-mediated inflammation. Clin. Immunol. 113(2): 119-129
    2. Gindraux, F. et al. (2007) Human and rodent bone marrow mesenchymal stem cells that express primitive stem cell markers can be directly enriched by using the CD49a molecule. Cell Tissue Res. 327(3): 471-483
    3. Chen, Y. et al. (2014) CD49a promotes T-cell-mediated hepatitis by driving T helper 1 cytokine and interleukin-17 production. Immunology 141(3): 388-400
Product options: 8
9 µg in 300 µL (1)
EUR 57,00 
30 µg in 1 mL (1)
EUR 82,00 
9 µg in 300 µL (1)
EUR 69,00 
30 µg in 1 mL (1)
EUR 103,00 
9 µg in 300 µL (1)
EUR 73,00 
30 µg in 1 mL (1)
EUR 103,00 
9 µg in 300 µL (1)
EUR 21,00 
30 µg in 1 mL (1)
EUR 41,00 

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