CD46 antibodies, human

CD46 antibodies, human

Clone: REA312 | Dilution: 1:11
Clone REA312 recognizes the human CD46 antigen, a type I transmembrane glycoprotein, which is also known as the membrane cofactor protein (MCP). At least fourteen different transcript variants encoding different isoforms have been found for CD46. It is expressed by a broad range of tissues including leukocytes, platelets, epithelial cells, and fibroblasts, but not by erythrocytes. CD46 acts as a co-factor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It is involved in the fusion of the spermatozoa with the oocyte during fertilization. Additionally, CD46 functions as a receptor for measles virus, human herpesvirus, and human adenovirus. It is a potent costimulator for the induction of interferon-γ secreting effector T helper type 1 cells and their subsequent switch into interleukin 10 producing regulatory T cells.
Additional information: Clone REA312 displays negligible binding to Fc receptors.

Alternative names

Membrane cofactor protein (MCP), AHUS2, MCP, MIC10, TLX, TRA2.10

Technical specifications

  • Antigen: CD46
  • Clone: REA312
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Membrane cofactor protein (MCP), AHUS2, MCP, MIC10, TLX, TRA2.10
  • Entrez Gene ID: 4179
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: leukocytes, platelets, epithelial cells, fibroblasts
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Le Friec, G. et al. (2012) The CD46-Jagged1 interaction is critical for human Tʜ1 immunity. Nat. Immunol. 13(12): 1213-1221
    2. Dörig, R. E. et al. (1993) The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75(2): 295-305
    3. Purcell, D. F. et al. (1991) Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation. Immunogenetics 33(5-6): 335-344
Product options: 14
130-104-556

CD46-FITC, human

for 30
tests
(1)
EUR 90,00 
130-104-507

CD46-FITC, human

for 100
tests
(1)
EUR 220,00 
130-104-557

CD46-PE, human

for 30
tests
(1)
EUR 110,00 
130-104-508

CD46-PE, human

for 100
tests
(1)
EUR 265,00 
130-104-558

CD46-APC, human

for 30
tests
(1)
EUR 110,00 
130-104-509

CD46-APC, human

for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 115,00 
for 100
tests
(1)
EUR 275,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 

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