CD44 antibodies, human

CD44 antibodies, human

Clone: REA690 | Dilution: 1:50
Clone REA690 recognizes the CD44 antigen. CD44 is a marker for many types of cancer stem cells (CSCs), including breast CSCs that possess higher tumorigenicity and metastatic potential, colorectal, pancreatic, and prostate CSCs. In addition, expression was observed in several cancers as well as on carcinoma cell lines. Here, CD44 plays a role in cancer cell migration and matrix adhesion in response to a cellular microenvironment, thus enhancing cellular aggregation and tumor cell growth. CD44 is also expressed on mesodermal cells, such as hematopoietic, fibroblastic, and glial cells.
Additional information: Clone REA690 displays negligible binding to Fc receptors.

Alternative Names

CD44s, EMCR III, H-CAM, Pgp-1

Technical specifications

  • Antigen: CD44
  • Clone: REA690
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD44s, EMCR III, H-CAM, Pgp-1
  • Entrez Gene ID: 960
  • Molecular mass of antigen [kDa]: 79
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: bone marrow, cancer stem cells, CNS cells, endothelial cells, epithelial cells, kidney, leukocytes, lymphocytes, mesenchymal stem cells, myeloid cells, plasma cells, ES and iPS cells, red blood cells, skeletal muscle, skin, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, Biotin, PerCP-Vio700
  • Selected References

    1. Al-Hajj, M. et al. (2003) Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 100: 3983-3988
    2. Dalerba, P. et al. (2007) Phenotypic characterization of human colorectal cancer stem cells. Proc. Natl. Acad. Sci. U.S.A. 104: 10158-10163
    3. Collins, A. T. et al. (2005) Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res. 65: 10946-10951
    4. Aruffo, A. et al. (1990) CD44 is the principal cell surface receptor for hyaluronate. Cell 61: 1303-1313
    5. Patrawala, L. et al. (2006)
      Highly purified CD44
      +
      prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells.
      Oncogene 25: 1696-1708
    6. Wang, L. et al. (2013) Enrichment of prostate cancer stem-like cells from human prostate cancer cell lines by culture in serum-free medium and chemoradiotherapy. Int. J. Biol. Sci. 9(5): 472-479
Product options: 16

Product information

Size
Order no.
Price

CD44-FITC, human

  • REA690
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-903
EUR 90,00 

CD44-FITC, human

  • REA690
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-341
EUR 220,00 

CD44-PE, human

  • REA690
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-904
EUR 110,00 

CD44-PE, human

  • REA690
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-342
EUR 265,00 

CD44-APC, human

  • REA690
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-900
EUR 110,00 

CD44-APC, human

  • REA690
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-338
EUR 265,00 

CD44-VioBlue, human

  • REA690
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-906
EUR 115,00 

CD44-VioBlue, human

  • REA690
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-344
EUR 275,00 

CD44-PE-Vio770, human

  • REA690
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-905
EUR 120,00 

CD44-PE-Vio770, human

  • REA690
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-343
EUR 290,00 

CD44-APC-Vio770, human

  • REA690
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-901
EUR 120,00 

CD44-APC-Vio770, human

  • REA690
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-339
EUR 290,00 

CD44-Biotin, human

  • REA690
  • 1:50
  • For research use only
for 30
tests
(1)
130-113-902
EUR 90,00 

CD44-Biotin, human

  • REA690
  • 1:50
  • For research use only
for 100
tests
(1)
130-113-340
EUR 220,00 

CD44-PerCP-Vio700, human

  • REA690
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-704
EUR 120,00 

CD44-PerCP-Vio700, human

  • REA690
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-614
EUR 290,00