CD40 antibodies, human

CD40 antibodies, human

Clone: HB14 | Dilution: 1:11
The HB14 monoclonal antibody reacts with human CD40, a 45–50 kDa type I transmembrane glycoprotein and member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed primarily on B cells, macrophages, dendritic cells, endothelial cells, and fibroblasts and at lower levels on plasma cells and a subset of peripheral T cells. CD40 is involved in B cell differentiation and proliferation, isotype class-switching, and protection of B cells from apoptosis. Interaction of CD40 with its ligand CD154 is important in T cell–B cell interaction and plays a role in co-stimulation and immune regulation. Clone HB14 blocks the binding of CD40 to CD154.

Alternative names

Bp50, CDW40, TNFRSF5, p50

Technical specifications

  • Antigen: CD40
  • Clone: HB14
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: Bp50, CDW40, TNFRSF5, p50
  • Entrez Gene ID: 958
  • Molecular mass of antigen [kDa]: 28
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, epithelial cells, fibroblasts, Langerhans cells, leukemia cells, lymphocytes, macrophages, mast cells, monocytes, plasma cells, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Kansas, G. S. et al. (1991) Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinasedependent pathway. J. Immunol. 147(12): 4094-4102
    2. Banchereau, J. et al. (1994) The CD40 antigen and its ligand. Annu. Rev. Immunol. 12: 881-926
Product options: 5
130-099-385

CD40-PE, human

for 30
tests
(1)
EUR 110,00 
130-094-135

CD40-PE, human

for 100
tests
(1)
EUR 265,00 
130-099-186

CD40-APC, human

for 30
tests
(1)
EUR 110,00 
130-094-137

CD40-APC, human

for 100
tests
(1)
EUR 265,00 
130-094-142

CD40-Biotin, human

for 100
tests
(1)
EUR 220,00