CD39 antibodies, human

CD39 antibodies, human

Clone: REA739 | Dilution: 1:50
Clone REA739 recognizes the 70–100 kDa membrane-bound human CD39 molecule, which is expressed on an effector/memory-like subset of FoxP3
+
regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. Together with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells.
Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells.
Additional information: Clone REA739 displays negligible binding to Fc receptors.

Alternative Names

Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80

Technical specifications

  • Antigen: CD39
  • Clone: REA739
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80
  • Entrez Gene ID: 953
  • Molecular mass of antigen [kDa]: 58
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, Biotin

Specificity

In order to compare the epitope specificity of REAfinity Clone REA739 with other known clones, a competition assay was performed. 
 Cells were incubated with an excess of purified unconjugated REAfinity Antibody followed by staining with fluorochrome-conjugated antibodies of other known clones against the same marker. Based on the fluorescence signal obtained, the clones were identified as recognizing completely overlapping (++), partially overlapping (+), or completely different epitopes (-) of the marker.
 

Other clonesOverlap in epitope recognition with REA739
MZ18-23C8++
A1++
TU66++
  • Selected references

    1. Maliszewski, C. R. et al. (1994) The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J. Immunol. 153(8): 3574-3583
    2. Kaczmarek, E. et al. (1996) Identification and characterization of CD39/vascular ATP diphosphohydrolase. J. Biol. Chem. 271(51): 33116-33122
    3. Borsellino, G. et al. (2007)
      Expression of ectonucleotidase CD39 by FoxP3
      +
      reg cells: hydrolysis of extracellular ATP and immune suppression.
      Blood 110: 1225-1232
Product options: 14
130-110-792

CD39-VioBright FITC, human

for 30
tests
(1)
EUR 120,00 
130-110-654

CD39-VioBright FITC, human

for 100
tests
(1)
EUR 290,00 
130-110-788

CD39-PE, human

for 30
tests
(1)
EUR 110,00 
130-110-650

CD39-PE, human

for 100
tests
(1)
EUR 265,00 
130-110-789

CD39-APC, human

for 30
tests
(1)
EUR 110,00 
130-110-651

CD39-APC, human

for 100
tests
(1)
EUR 265,00 
130-110-794

CD39-PE-Vio615, human

for 30
tests
(1)
EUR 120,00 
130-110-656

CD39-PE-Vio615, human

for 100
tests
(1)
EUR 290,00 
130-110-790

CD39-PE-Vio770, human

for 30
tests
(1)
EUR 120,00 
130-110-652

CD39-PE-Vio770, human

for 100
tests
(1)
EUR 290,00 
130-110-791

CD39-APC-Vio770, human

for 30
tests
(1)
EUR 120,00 
130-110-653

CD39-APC-Vio770, human

for 100
tests
(1)
EUR 290,00 
130-110-787

CD39-Biotin, human

for 30
tests
(1)
EUR 90,00 
130-110-649

CD39-Biotin, human

for 100
tests
(1)
EUR 220,00