CD38 antibodies, human

CD38 antibodies, human

Clone: REA572 | Dilution: 1:11
Clone REA572 recognizes the human CD38 antigen, a single-chain type II transmembrane glycoprotein with enzymatic activity. It is present on the majority of hematopoietic cells, prevalent during early differentiation and activation processes. Terminally differentiated B cells (plasma cells) express CD38 brightly. Furthermore, CD38 is constitutively expressed in several tissues, for example brain, muscle, and kidney. CD38, a disease marker for human leukemias and myelomas, plays a role in the pathogenesis and outcome of human immunodeficiency virus infection and chronic lymphocytic leukemia, and controls insulin release and also the development of diabetes. Furthermore it catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD
+
to ADP-ribose which is essential for the regulation of intracellular Ca
2+
.
Additional information: Clone REA572 displays negligible binding to Fc receptors.

Alternative Names

ADPRC 1, ADPRC1, T10

Technical specifications

  • Antigen: CD38
  • Clone: REA572
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ADPRC 1, ADPRC1, T10
  • Entrez Gene ID: 952
  • Molecular mass of antigen [kDa]: 34
  • Distribution of antigen: B cells, basophils, bone marrow, brain, kidney, leukocytes, lymphocytes, monocytes, myeloid cells, NK cells, ovary, pancreatic carcinoma cells, placenta, plasma cells, red blood cells, skeletal muscle, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE-Vio770, Biotin
REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the other known clones. 
Other clonesOverlap in epitope recognition with REA572
HB7++
HIT2++
IB6++
REA671++

Related products

3 products available
Product options: 4

Product information

Size
Order no.
Price

CD38-PE-Vio770, human

  • REA572
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-864
EUR 144,00 

CD38-PE-Vio770, human

  • REA572
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-838
EUR 317,00 

CD38-Biotin, human

  • REA572
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-861
EUR 85,00 

CD38-Biotin, human

  • REA572
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-835
EUR 248,00