CD370 (CLEC9A) antibodies, human

CD370 (CLEC9A) antibodies, human

Clone: REA976 | Dilution: 1:50
Clone REA976 recognizes the human CD370 antigen, also known as C-type lectin domain family 9 member A (CLEC9A). CD370 is a type II transmembrane glycoprotein member of 241 amino acids with a predicted molecular mass of ~30 kDa. It is also known as DNGR-1 and is expressed on BDCA-3
+
myeloid dendritic cells from peripheral blood and lymphoid tissues. CD370 acts as a receptor for necrotic cells and plays an important role in cross-presentation.
Additional information: Clone REA976 displays negligible binding to Fc receptors.

Alternative Names

DNGR-1, C-type lectin family member 9A

Technical specifications

  • Antigen: CD370 (CLEC9A)
  • Clone: REA976
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: DNGR-1, C-type lectin family member 9A
  • Entrez Gene ID: 283420
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected References

    1. Poulin, L. F. et al. (2010)
      Characterization of human DNGR-1
      +
      BDCA3
      +
      leukocytes as putative equivalents of mouse CD8 alpha
      +
      dendritic cells.
      J. Exp. Med. 207(6): 1261-1271
    2. Sancho, D. et al. (2008) Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J. Clin. Invest. 118(6): 2098-2110
    3. Sancho, D. et al. (2009) Identification of a dendritic cell receptor that couples sensing of necrosis to immunity. Nature 458(7240): 899-903
Product options: 8
130-116-416

CD370 (CLEC9A)-FITC, human

for 30
tests
(1)
EUR 90,00 
130-116-352

CD370 (CLEC9A)-FITC, human

for 100
tests
(1)
EUR 220,00 
130-116-417

CD370 (CLEC9A)-PE, human

for 30
tests
(1)
EUR 110,00 
130-116-353

CD370 (CLEC9A)-PE, human

for 100
tests
(1)
EUR 265,00 
130-116-418

CD370 (CLEC9A)-APC, human

for 30
tests
(1)
EUR 110,00 
130-116-354

CD370 (CLEC9A)-APC, human

for 100
tests
(1)
EUR 265,00 
130-116-415

CD370 (CLEC9A)-Biotin, human

for 30
tests
(1)
EUR 90,00 
130-116-351

CD370 (CLEC9A)-Biotin, human

for 100
tests
(1)
EUR 220,00