CD357 (GITR) antibodies – functional grade, mouse

CD357 (GITR) antibodies – functional grade, mouse

Clone: DTA-1
Clone DTA-1 specifically recognizes mouse CD357, also known as glucocorticoid-induced TNF-receptor (GITR) or TNFRSF18, a member of the tumor necrosis factor receptor (TNFR) superfamily. Human and mouse orthologs share about 60% homology.
CD357 is expressed at low levels on resting T lymphocytes and at high levels on CD4
+
CD25
+
regulatory T cells (Tregs). Activation of T cells upregulates CD357 expression. Interaction of CD357 with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. CD357 plays an important role in the function of CD4
+
CD25
+
Tregs. Clone DTA-1 is a non-depleting, agonistic antibody reported to abrogate regulatory T cell funtion
in vivo
and
in vitro
.

Applications

The CD357 (GITR) pure – functional grade antibody is suited for functional assays, for example,
in vitro
costimulation of T cells and
in vivo
GITR stimulation.

Alternative Names

TNFRSF18, AITR

Technical specifications

  • Antigen: CD357 (GITR)
  • Clone: DTA-1
  • Isotype: rat IgG2bκ
  • Alternative names of antigen: TNFRSF18, AITR
  • Entrez Gene ID: 21936
  • Molecular mass of antigen [kDa]: 23
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
Product options: 2

Product information

Size
Order no.
Price

CD357 (GITR) pure - functional grade, mouse

  • DTA-1
  • For research use only
100 µg in 1 mL
130-092-655
EUR 191,00 

CD357 (GITR) pure - functional grade, mouse

  • DTA-1
  • For research use only
1 mg in 0.5 mL
130-092-656
EUR 1.289,00 

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