CD357 (GITR) antibodies – functional grade, human

CD357 (GITR) antibodies – functional grade, human

Clone: DT5D3
CD357, also known as glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) or TNFRSF18, is an inducible type I transmembrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily.
CD357 is expressed at low levels on thymocyte subsets, resting T cells, B cells, macrophages, and at high levels on CD4
+
CD25
+
regulatory T cells (Tregs). Upon activation, expression on CD4
+
and CD8
+
T cells is upregulated. Triggering of CD357 has been described to modulate Treg function and costimulate effector T cells. Stimulation of T cells through CD357 can abrogate the inhibitory function of Tregs. It is hypothesized that CD357 has a role in the maintenance of immunological self tolerance, and mouse models of autoimmune disease suggest that CD357 activation may break self-tolerance and induce autoimmunity.

Applications

The CD357 (GITR) pure – functional grade antibody is suited for functional assays, for example,
in vitro
inhibition of GITRL binding.

Alternative Names

TNFRSF18, AITR, GITR-D

Technical specifications

  • Antigen: CD357 (GITR)
  • Clone: DT5D3
  • Isotype: mouse IgG1
  • Alternative names of antigen: TNFRSF18, AITR, GITR-D
  • Entrez Gene ID: 8784
  • Molecular mass of antigen [kDa]: 24
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
Product options: 1

Product information

Size
Order no.
Price

CD357 (GITR) pure - functional grade, human

  • DT5D3
  • For research use only
500 µg in 0.5 mL
130-093-052
EUR 463,00 

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