CD354 (TREM-1) antibodies, human

CD354 (TREM-1) antibodies, human

Clone: REA213 | Dilution: 1:11
Clone REA213 recognizes the human CD354 (TREM-1), a 30 kDa member of the triggering receptors expressed on myeloid cells (TREM) family of cell surface receptors. TREM receptors are immunoglobulin 'superfamily' members and contain a single variable-type immunoglobulin domain. Human TREM cluster is located on chromosome 6p21. Expression of TREM-1 is found on the cell surface of myeloid cells such as neutrophils, monocytes, dendritic cells, and macrophages. TREM-1 signals via ITAM-containing adaptor DAP12 and serves as an amplifier of cell activation in response to triggers such as LPS. TREM-1 activated cellular signalling molecules and pathways lead to generation of pro-inflammatory response such as expression and secretion of chemokines and cytokines including MCP-1, MIP-1a, interleukin 6 (IL-6), IL-8, and TNF. TREM-1 acts in a concerted manner with other signalling receptors such as TLRs and Nod-like receptors, leading to an amplification of the initial response. Expression of TREM-1 itself is upregulated in response to presence of LPS, microbial products, and cytokines released during activation response. A soluble form of TREM-1 (sTREM-1) is also detected in fluids from patients with infections.
Additional information: Clone REA213 displays negligible binding to Fc receptors.

Alternative names

TREM1

Technical specifications

  • Antigen: CD354 (TREM-1)
  • Clone: REA213
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TREM1
  • Distribution of antigen: dendritic cells, macrophages, neutrophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PerCP-Vio700, Biotin, FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770
  • Selected references

Product options: 16
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EUR 227,00 
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EUR 113,00 
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tests
(1)
EUR 273,00 
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tests
(1)
EUR 113,00 
for 100
tests
(1)
EUR 273,00 
for 30
tests
(1)
EUR 118,00 
for 100
tests
(1)
EUR 283,00 
for 30
tests
(1)
EUR 124,00 
for 100
tests
(1)
EUR 299,00 
for 30
tests
(1)
EUR 124,00 
for 100
tests
(1)
EUR 299,00 
for 30
tests
(1)
EUR 124,00 
for 100
tests
(1)
EUR 299,00 
for 30
tests
(1)
EUR 93,00 
for 100
tests
(1)
EUR 227,00 

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