CD352 (NTB-A) antibodies, human

CD352 (NTB-A) antibodies, human

Clone: REA339 | Dilution: 1:50
Clone REA339 recognizes the human CD352 antigen, a 60 kDa single-pass type I membrane protein also known as SLAM family member 6 (SLAM6) or natural killer (NK), T, and B cell–antigen (NTB-A). CD352 belongs to the CD2 subfamily of the immunoglobulin superfamily and is expressed on NK, T, and B cells. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases. Monoclonal antibody-mediated cross-linking of CD352 results in the induction of NK-mediated cytotoxicity. CD352 also triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors. This suggests that CD352 may function as a coreceptor in the process of NK cell activation. Importantly, analysis of NK cells derived from patients with X-linked lymphoproliferative disease showed that the lack of SH2D1A protein profoundly affects the function of CD352.
Additional information: Clone REA339 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: CD352 (NTB-A)
  • Clone: REA339
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SLAMF6, KALI, KALIb, LY108, NTB-A, NTBA, SF2000, SLAM6, TCOM
  • Entrez Gene ID: 114836
  • Molecular mass of antigen [kDa]: 35
  • Distribution of antigen: NK cells, B cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Katz, G. et al. (2014) SAP facilitates recruitment and activation of LCK at NTB-A receptors during restimulation-induced cell death. J. Immunol. 192(9): 4202-4209
    2. Bottino, C. et al. (2001) NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease. J. Exp. Med. 194(3): 235-246
    3. Valdez, P. A. et al. (2004) NTB-A, a new activating receptor in T cells that regulates autoimmune disease. J. Biol. Chem. 279(18): 18662-18669
Product options: 2
for 30
EUR 113,00 
for 100
EUR 273,00 

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