CD335 (NKp46) antibodies, human

CD335 (NKp46) antibodies, human

Clone: REA808 | Dilution: 1:50
Clone REA808 recognizes the CD335 antigen, a type I membrane glycoprotein also known as NKp46. CD335 is a member of the natural cytotoxicity receptor (NCR) family which trigger cytotoxicity in NK cells and mediates cell activation. CD335 is directly involved in target cell recognition and lysis and is exclusively expressed on CD3
CD56
+
NK cells, suggesting it to be a universal marker for NK cells.
Additional information: Clone REA808 displays negligible binding to Fc receptors.

Alternative names

NK-p46, hNKp46, NCR1, LY94

Technical specifications

  • Antigen: CD335 (NKp46)
  • Clone: REA808
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: NK-p46, hNKp46, NCR1, LY94
  • Entrez Gene ID: 9437
  • Molecular mass of antigen [kDa]: 32
  • Distribution of antigen: NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, VioBright 515, Biotin
  • Selected references

    1. Pessino, A. et al. (1998) Molecular cloning of NKp46: A novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J. Exp. Med. 188: 953-960
    2. Sivori, S. et al. (2000) 2B4 functions as a co-receptor in human NK cell activation. Eur. J. Immunol. 30: 787-793
    3. Moretta, A. et al. (2001) Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol. 19: 197-223
    4. Moretta, L. and Moretta, A. (2004) Unravelling natural killer function: Triggering and inhibitory human NK receptors. EMBO J. 23: 255-259
    5. Lai, C. B. et al. (2012) Role of runt-related transcription factor 3 (RUNX3) in transcription regulation of natural cytotoxicity receptor 1 (NCR1/NKp46), an activating natural killer (NK) cell receptor. J. Biol. Chem. 287(10): 7324-7334
Product options: 12
130-112-279

CD335 (NKp46)-PE, human

for 30
tests
(1)
EUR 110,00 
130-112-121

CD335 (NKp46)-PE, human

for 100
tests
(1)
EUR 265,00 
130-112-280

CD335 (NKp46)-APC, human

for 30
tests
(1)
EUR 110,00 
130-112-122

CD335 (NKp46)-APC, human

for 100
tests
(1)
EUR 265,00 
130-112-277

CD335 (NKp46)-PE-Vio615, human

for 30
tests
(1)
EUR 120,00 
130-112-119

CD335 (NKp46)-PE-Vio615, human

for 100
tests
(1)
EUR 290,00 
130-112-281

CD335 (NKp46)-PE-Vio770, human

for 30
tests
(1)
EUR 120,00 
130-112-123

CD335 (NKp46)-PE-Vio770, human

for 100
tests
(1)
EUR 290,00 
130-112-278

CD335 (NKp46)-VioBright 515, human

for 30
tests
(1)
EUR 150,00 
130-112-120

CD335 (NKp46)-VioBright 515, human

for 100
tests
(1)
EUR 360,00 
130-112-276

CD335 (NKp46)-Biotin, human

for 30
tests
(1)
EUR 90,00 
130-112-118

CD335 (NKp46)-Biotin, human

for 100
tests
(1)
EUR 220,00