CD32 antibodies, human

CD32 antibodies, human

Clone: 2E1
CD32, also known as FcγRII, is a 40 kDa low affinity receptor for the Fc fragment of aggregated IgG. Due to alternative splicing three different isoforms of CD32 are expressed on hematopoietic cells: FcRIIA, FcRIIB, and FcRIIC. The cytoplasmic domains of FcRIIA and FcRIIC contain an activatory ITAM motif whereas FcRIIB is an inhibitory receptor containing an ITIM motif. Different isoforms of CD32 are expressed on B cells, monocytes, dendritic cells, granulocytes, and platelets. The monoclonal antibody 2E1 recognizes all isoforms of CD32 without blocking the binding of immune complexes.

Alternative names

FCGR2A, CD32A, CDw32, FCG2, FCGR21, FcGR, IGFR2, FCGR2B, CD32B, FcγRII

Technical specifications

  • Antigen: CD32
  • Clone: 2E1
  • Isotype: mouse IgG2a
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: FCGR2A, CD32A, CDw32, FCG2, FCGR21, FcGR, IGFR2, FCGR2B, CD32B, FcγRII
  • Entrez Gene ID: 2212
  • Molecular mass of antigen [kDa]: 31
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    , baboon, horse
  • Distribution of antigen: B cells, basophils, dendritic cells, endothelial cells, eosinophils, granulocytes, Langerhans cells, leukocytes, lymphocytes, macrophages, monocytes, myeloid cells, neutrophils, NK cells, placenta, plasma cells, platelets
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates:
  • Selected references

    1. Van Den Herik-Oudijk, I. E. et al. (1994) Functional analysis of human Fc gamma RII (CD32) isoforms expressed in B lymphocytes. J. Immunol. 152(2): 574-585
    2. Båve, U. et al. (2003) Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG. J. Immunol. 171(6): 3296-3302
Product options: 1
130-108-021

CD32 pure, human

100 µg in 100 µL
EUR 163,00