CD314 (NKG2D) antibodies, mouse

CD314 (NKG2D) antibodies, mouse

Clone: CX5 | Dilution: 1:10
Clone CX5 recognizes mouse CD314 (NKG2D), a type II transmembrane homodimeric glycoprotein belonging to the C-type lectin-like receptor family. CD314 in mice is expressed on activated CD8
+
αβ T cells, NK cells, subsets of γδ T cells, IFN-producing killer dendritic cells, subsets of NKT cells, and activated macrophages. For signaling, CD314 associates with signaling adapters DAP10 and DAP12 and transduces signal via the PI3-kinase pathway and the Syk-Zap70 pathways, respectively. CD314 recognizes multiple ligands, which are either uregulated in response to cellular stresses such as heat shock, infection, and DNA damage or are constitutively expressed, such as on tumor cells. Known ligands of CD314 in mice include murine UL16-binding protein-like transcript (MULTI), H60 family proteins and the five retinoic acid-inducible proteins RAE-1α, β, γ, δ, ε. Interaction of CD314 with its ligands regulates cytotoxic response towards the cells bearing the cognate ligands.

Alternative Names

Klrk1, NKG2-D, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member, Nkg2d

Technical specifications

  • Antigen: CD314 (NKG2D)
  • Clone: CX5
  • Isotype: rat IgG1κ
  • Isotype control: Rat IgG1 – isotype control antibodies
  • Alternative names of antigen: Klrk1, NKG2-D, NKG2-D type II integral membrane protein, Killer cell lectin-like receptor subfamily K member, Nkg2d
  • Entrez Gene ID: 27007
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: T cells, NK cells, macrophages, dendritic cells, NKT cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
Product options: 8

Product information

Size
Order no.
Price

CD314 (NKG2D)-PE, mouse

  • CX5
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-103-367
EUR 27,00 

CD314 (NKG2D)-PE, mouse

  • CX5
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-102-728
EUR 54,00 

CD314 (NKG2D)-APC, mouse

  • CX5
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-103-368
EUR 44,00 

CD314 (NKG2D)-APC, mouse

  • CX5
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-102-729
EUR 86,00 

CD314 (NKG2D)-PE-Vio770, mouse

  • CX5
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-103-369
EUR 44,00 

CD314 (NKG2D)-PE-Vio770, mouse

  • CX5
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-102-730
EUR 86,00 

CD314 (NKG2D)-Biotin, mouse

  • CX5
  • 1:10
  • For research use only
9 µg in 300 µL (1)
130-102-127
EUR 15,00 

CD314 (NKG2D)-Biotin, mouse

  • CX5
  • 1:10
  • For research use only
30 µg in 1 mL (1)
130-101-981
EUR 32,00 

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