CD282 (TLR2) antibodies, human and mouse

CD282 (TLR2) antibodies, human and mouse

Clone: REA109
Clone REA109 recognises human and mouse CD282, also known as toll-like receptor 2 (TLR2). TLRs are the host pattern recognition receptors involved in recognising pathogen associated and certain tissue damage indicating molecules. They are type 1 transmembrane proteins with extracellular leucine-rich repeats and intracellular toll/IL-1 receptor domains. TLR2 is a plasma membrane associated TLR and recognizes various structurally diverse molecules including peptidoglycans (PG), lipopeptides and lipoproteins moieties in Gram
and Gram
bacteria, lipoteichoic acid (LTA) in Gram
bacteria, lipoarabinomannan and lipomannan from Mycoplasma, and fungal polysaccharides such as zymogen. High-resolution crystal structures suggested that TLR2 by forming heterodimers with TLR6 and TLR1 can distinguish between di-acylated and tri-acylated lipopeptides. The expression of CD282 (TLR2) is found on monocytes, granulocytes, dendritic, endothelial, and epithelial cells.
Additional information: Clone REA109 displays negligible binding to Fc receptors.

Alternative names

TLR2, TIL4, Ly105

Technical specifications

  • Antigen: CD282 (TLR2)
  • Clone: REA109
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TLR2, TIL4, Ly105
  • Entrez Gene ID: 7097
  • Molecular mass of antigen [kDa]: 88
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Kirschning, C. J. and Schumann, R. R. (2002) TLR2: cellular sensor for microbial and endogenous molecular patterns. Curr Top Microbiol Immunol. 270: 121-144
    2. Takeda, K. and Akira, S. (2005) Toll-like receptors in innate immunity. Int. Immunol. 17: 1-14
    3. Kang, J. Y. et al. (2009) Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity 31(6): 873-884
Product options: 1
100 µg in 100 µL
EUR 189,00