CD278 (ICOS) antibodies, human, mouse, rat

CD278 (ICOS) antibodies, human, mouse, rat

Clone: REA192 | Dilution: 1:11
Clone REA192 recognizes CD278 (ICOS), which belongs to the CD28 family of proteins. CD28 family members are co-stimulatory receptor molecules, contain single immunoglobulin V-like domain, and belong to the immunoglobulin superfamily. CD287 recognizes ICOSL (inducible T cell co-stimulator ligand) as ligand and its expression is induced on activated T cells. Enhanced expression of CD278 is also observed on T cells, followed by co-stimulation of T cells via CD28. Further expression of CD278 is found on B cells, monocytes, and dendritic cells. Crosslinking of ICOS on T cell surface in the presence of primary stimulation signal leads to T cell proliferation and differentiation. In addition, CD278 plays role in Tʜ cell differentiation, effector T cell function, and isotype class switching.
Additional information: Clone REA192 displays negligible binding to Fc receptors.

Alternative Names

ICOS, AILIM, CVID1

Technical specifications

  • Antigen: CD278 (ICOS)
  • Clone: REA192
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ICOS, AILIM, CVID1
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin

REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the other known clones. 

Other clonesOverlap in epitope recognition with REA192
DX29++
ISA-3++
C398.4A++
Product options: 18

Product information

Size
Order no.
Price

CD278 (ICOS)-FITC, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 30
tests
(1)
130-100-734
EUR 74,00 

CD278 (ICOS)-FITC, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 100
tests
(1)
130-100-732
EUR 185,00 

CD278 (ICOS)-APC, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 30
tests
(1)
130-100-719
EUR 113,00 

CD278 (ICOS)-APC, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 100
tests
(1)
130-100-721
EUR 253,00 

CD278 (ICOS)-VioBlue, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 30
tests
(1)
130-100-639
EUR 91,00 

CD278 (ICOS)-VioBlue, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 100
tests
(1)
130-100-737
EUR 241,00 

CD278 (ICOS)-VioGreen, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 30
tests
(1)
130-100-740
EUR 113,00 

CD278 (ICOS)-VioGreen, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 100
tests
(1)
130-100-739
EUR 344,00 

CD278 (ICOS)-PE-Vio615, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 30
tests
(1)
130-107-512
EUR 148,00 

CD278 (ICOS)-PE-Vio615, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 100
tests
(1)
130-107-458
EUR 326,00 

CD278 (ICOS)-PE-Vio770, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 30
tests
(1)
130-100-736
EUR 113,00 

CD278 (ICOS)-PE-Vio770, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 100
tests
(1)
130-100-735
EUR 278,00 

CD278 (ICOS)-APC-Vio770, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 30
tests
(1)
130-100-727
EUR 101,00 

CD278 (ICOS)-APC-Vio770, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 100
tests
(1)
130-100-723
EUR 278,00 

CD278 (ICOS)-PerCP-Vio700, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 30
tests
(1)
130-100-733
EUR 113,00 

CD278 (ICOS)-PerCP-Vio700, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 100
tests
(1)
130-100-731
EUR 300,00 

CD278 (ICOS)-Biotin, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 30
tests
(1)
130-100-726
EUR 74,00 

CD278 (ICOS)-Biotin, human, mouse, rat

  • REA192
  • 1:11
  • For research use only
for 100
tests
(1)
130-100-728
EUR 236,00 

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