CD275 (B7-H2) antibodies, mouse

CD275 (B7-H2) antibodies, mouse

Clone: REA990 | Dilution: 1:50
Clone REA990 recognises the mouse CD275 antigen, which is also known as B7-H2 or ICOSL. CD275 is a type I membrane protein and belongs to the Ig superfamily, B7 family of co-stimulatory molecules. Expression of CD275 is found on antigen presenting cells such as B cells, dendritic cells, and monocytes. CD275 co-stimulates T cells upon binding to inducible T cell co-stimulator (ICOS), which is expressed on activated T cells. In mouse, CD275 binds only ICOS, whereas in humans it can interact with other T cell co-stimulatory molecules, CD28 and CTLA-4. To appropriately regulate the activation of immune response, the ICOS-CD275 interaction can also lead to downregulation of CD275 expression which allows prevention of hyperreaction of T cells.
Additional information: Clone REA990 displays negligible binding to Fc receptors.

Alternative Names

ICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, GL50

Technical specifications

  • Antigen: CD275 (B7-H2)
  • Clone: REA990
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: ICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, GL50
  • Entrez Gene ID: 50723
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: dendritic cells, macrophages, monocytes, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, VioBright 515, Biotin

Related products

2 products available
Product options: 10

Product information

Size
Order no.
Price

CD275 (B7-H2)-PE, mouse

  • REA990
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-116-446
EUR 57,00 

CD275 (B7-H2)-PE, mouse

  • REA990
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-116-382
EUR 224,00 

CD275 (B7-H2)-APC, mouse

  • REA990
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-116-447
EUR 83,00 

CD275 (B7-H2)-PE-Vio615, mouse

  • REA990
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-116-451
EUR 101,00 

CD275 (B7-H2)-PE-Vio615, mouse

  • REA990
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-116-387
EUR 298,00 

CD275 (B7-H2)-PE-Vio770, mouse

  • REA990
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-116-448
EUR 101,00 

CD275 (B7-H2)-VioBright 515, mouse

  • REA990
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-116-450
EUR 107,00 

CD275 (B7-H2)-VioBright 515, mouse

  • REA990
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-116-386
EUR 398,00 

CD275 (B7-H2)-Biotin, mouse

  • REA990
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-116-444
EUR 32,00 

CD275 (B7-H2)-Biotin, mouse

  • REA990
  • 1:50
  • For research use only
150 µg in 1 mL (1)
130-116-380
EUR 147,00