CD275 (B7-H2) antibodies, mouse

CD275 (B7-H2) antibodies, mouse

Clone: REA990 | Dilution: 1:50
Clone REA990 recognises the mouse CD275 antigen, which is also known as B7-H2 or ICOSL. CD275 is a type I membrane protein and belongs to the Ig superfamily, B7 family of co-stimulatory molecules. Expression of CD275 is found on antigen presenting cells such as B cells, dendritic cells, and monocytes. CD275 co-stimulates T cells upon binding to inducible T cell co-stimulator (ICOS), which is expressed on activated T cells. In mouse, CD275 binds only ICOS, whereas in humans it can interact with other T cell co-stimulatory molecules, CD28 and CTLA-4. To appropriately regulate the activation of immune response, the ICOS-CD275 interaction can also lead to downregulation of CD275 expression which allows prevention of hyperreaction of T cells.
Additional information: Clone REA990 displays negligible binding to Fc receptors.

Alternative Names

ICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, GL50

Technical specifications

  • Antigen: CD275 (B7-H2)
  • Clone: REA990
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: ICOSL, B7-H2, B7RP-1, B7h, ICOSLG, LICOS, Ly115l, GL50
  • Entrez Gene ID: 50723
  • Molecular mass of antigen [kDa]: 31
  • Distribution of antigen: dendritic cells, macrophages, monocytes, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, VioBright 515, Biotin
  • Selected References

    1. Watanabe, M. et al. (2008) Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses. J. Immunol. 180: 5222-5234
    2. Yao, S. et al. (2011) B7-H2 is a costimulatory ligand for CD28 in human. Immunity 34(5): 729-740

Related products

2 products available
Product options: 10
130-116-446

CD275 (B7-H2)-PE, mouse

30 µg in 200 µL (1)
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CD275 (B7-H2)-PE, mouse

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CD275 (B7-H2)-APC, mouse

30 µg in 200 µL (1)
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CD275 (B7-H2)-PE-Vio615, mouse

30 µg in 200 µL (1)
EUR 100,00 
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CD275 (B7-H2)-PE-Vio615, mouse

150 µg in 1 mL (1)
EUR 295,00 
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CD275 (B7-H2)-PE-Vio770, mouse

30 µg in 200 µL (1)
EUR 100,00 
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CD275 (B7-H2)-VioBright 515, mouse

30 µg in 200 µL (1)
EUR 145,00 
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CD275 (B7-H2)-VioBright 515, mouse

150 µg in 1 mL (1)
EUR 420,00 
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CD275 (B7-H2)-Biotin, mouse

30 µg in 200 µL (1)
EUR 40,00 
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CD275 (B7-H2)-Biotin, mouse

150 µg in 1 mL (1)
EUR 120,00