CD271 (LNGFR) antibodies, human and mouse

CD271 (LNGFR) antibodies, human and mouse

Clone: REA648 | Dilution: 1:11
Clone REA648 recognizes the CD271 antigen, a type I transmembrane glycophosphoprotein, also known as low-affinity nerve growth factor receptor (LNGFR) or p75 neurotrophin receptor (p75 NTR). CD271 belongs to the low-affinity neurotrophin receptors and the tumor necrosis factor receptor superfamily. Initially the human CD271 was described to be expressed on cells of the central and peripheral nervous system, and was suggested to be involved in the development, survival, and differentiation of cells. Binding of neutrophins to the CD271 receptor initiates the stimulation of neuronal cells to survive and differentiate. CD271 is expressed on mesenchymal stem/stromal cells (MSCs), follicular dendritic cells, mesenchymal cells involved in mesenchymal-epithelial interactions, autonomic and sensory neurons, oligodendrocytes, astrocytes, schwann cells, and neural crest stem cells.
Additional information: Clone RE648 displays negligible binding to Fc receptors.

Alternative names

NGFR (p75), p75NGFR, p75NTR, TNFRSF16, CD271, Gp80-LNGFR

Technical specifications

  • Antigen: CD271 (LNGFR)
  • Clone: REA648
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: NGFR (p75), p75NGFR, p75NTR, TNFRSF16, CD271, Gp80-LNGFR
  • Entrez Gene ID: 18053
  • Molecular mass of antigen [kDa]: 42
  • Cross-reactivity: guinea pig, rat,
    rhesus monkey (
    Macaca mulatta
  • Distribution of antigen: stromal cells, mesenchymal stem cells, dendritic cells, oligodendrocytes, Schwann cells, neural stem cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC-Vio770, VioBright FITC
  • Selected references

    1. Thomson, T. M. et al. (1988) Expression of human nerve growth factor receptor on cells derived from all three germ layers. Exp. Cell Res. 174: 533-539
    2. Pezzati, P. et al. (1992) Expression of nerve growth factor receptor immunoreactivity on follicular dendritic cells from human mucosa associated lymphoid tissues. Immunology 76: 485-490
    3. Rudge, J. S. et al. (1994) Neurotrophic factor receptors and their signal transduction capabilities in rat astrocytes. Eur. J. Neurosci. 6: 693-705
    4. Kashiba, H. et al. (1995) Coexpression of trk family members and low-affinity neurotrophin receptors in rat dorsal root ganglion neurons. Brain Res. Mol. Brain Res. 30(1): 158-164
    5. Caneva, L. et al. (1995) Immuno-electron microscopy characterization of human bone marrow stromal cells with anti-NGFR antibodies. Blood Cells Mol. Dis. 21: 73-85
    6. Huber, L. J. and Chao, M. V. (1995) Mesenchymal and neuronal cell expression of the p75 neurotrophin receptor gene occur by different mechanisms. Dev. Biol. 167: 227-238
    7. Casaccia-Bonnefil, P. et al. (1996) Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 383: 716-719
    8. Chalazonitis, A. et al. (1998)
      Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: expression of GFRalpha-1
      in vitro
      in vivo
      Dev. Biol. 204(2): 385-406
    9. Jones, E. A. et al. (2002) Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum. 46: 3349-3360
    10. Quirici, N. et al. (2002) Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies. Exp. Hematol. 30: 783-791
    11. Vroemen, M. and Weidner, N. (2003) Purification of Schwann cells by selection of p75 low affinity nerve growth factor receptor expressing cells from adult peripheral nerve. J. Neurosci. Methods 124: 135-143
    12. Rozemuller, H. et al. (2010) Prospective isolation of mesenchymal stem cells from multiple mammalian species using cross-reacting anti-human monoclonal antibodies. Stem Cells Dev. 19: 1911-1921
  • Scientific posters

Product options: 3
for 30
EUR 124,00 
for 30
EUR 124,00 
for 100
EUR 299,00 

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