CD258 (LIGHT) antibodies, human

CD258 (LIGHT) antibodies, human

Clone: REA244 | Dilution: 1:11
Clone REA244 recognizes the CD258 antigen, a type II transmembrane protein, which is also known as tumor necrosis factor ligand superfamily member 14 (TNFSF14), herpes virus entry mediator ligand (HVEML), or LIGHT, the acronym for “homologous to lymphotoxins, inducible expression, competes with HSV glycoprotein D for HVEM, a receptor expressed on T lymphocytes”. CD258 is expressed by activated T cells, NK cells, monocytes, granulocytes, and immature dendritic cells. The ligands of CD258 are HVEM, lymphotoxin β receptor, and decoy receptor DcR3/TR6. CD258 has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. CD258 is also reported to prevent tumor necrosis factor alpha–mediated apoptosis in primary hepatocytes. Its blockade or targeted disruption can alleviate alloresponses, graft rejection, or graft-versus-host disease.
Additional information: Clone REA244 displays negligible binding to Fc receptors.

Alternative Names

TNFSF14, HVEML, LIGHT, LTg, TR2

Technical specifications

  • Antigen: CD258 (LIGHT)
  • Clone: REA244
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TNFSF14, HVEML, LIGHT, LTg, TR2
  • Entrez Gene ID: 8740
  • Molecular mass of antigen [kDa]: 26
  • Distribution of antigen: dendritic cells, granulocytes, monocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
  • Selected References

    1. Morel, Y. et al. (2000) Reciprocal expression of the TNF family receptor herpes virus entry mediator and its ligand LIGHT on activated T cells: LIGHT down-regulates its own receptor. J. Immunol. 165: 4397-4404
    2. Mauri, D. N. et al. (1998) LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator. Immunity 8(1): 21-30
    3. Heo, S-K. et al. (2006) LIGHT enhances the bactericidal activity of human monocytes and neutrophils via HVEM. J. Leukoc. Biol. 79: 330-338
Product options: 10
130-103-723

CD258 (LIGHT)-FITC, human

for 30
tests
(1)
EUR 90,00 
130-103-658

CD258 (LIGHT)-FITC, human

for 100
tests
(1)
EUR 220,00 
130-103-724

CD258 (LIGHT)-PE, human

for 30
tests
(1)
EUR 110,00 
130-103-659

CD258 (LIGHT)-PE, human

for 100
tests
(1)
EUR 265,00 
130-103-725

CD258 (LIGHT)-APC, human

for 30
tests
(1)
EUR 110,00 
130-103-660

CD258 (LIGHT)-APC, human

for 100
tests
(1)
EUR 265,00 
130-103-726

CD258 (LIGHT)-PE-Vio770, human

for 30
tests
(1)
EUR 120,00 
130-103-661

CD258 (LIGHT)-PE-Vio770, human

for 100
tests
(1)
EUR 290,00 
130-103-766

CD258 (LIGHT)-Biotin, human

for 30
tests
(1)
EUR 90,00 
130-103-755

CD258 (LIGHT)-Biotin, human

for 100
tests
(1)
EUR 220,00