CD254 (RANKL) antibodies, mouse

CD254 (RANKL) antibodies, mouse

Clone: REA1026 | Dilution: 1:50
Clone REA1026 recognizes the mouse CD254 antigen, also known as receptor activator of nuclear factor kappa-B ligand (RANKL) or TNF-related activation-induced cytokine (TRANCE). CD254 is an essential osteoclastic differentiation and activation factor which has multiple roles in the immune system. It is reported that RANK and CD254 (RANKL) may be important regulators of interactions between T cells and dendritic cells and is involved in the regulation of the T cell–dependent immune response. CD254 is expressed on osteoplastsand dendritic cells.
Additional information: Clone REA1026 displays negligible binding to Fc receptors.

Technical specifications

  • Antigen: CD254 (RANKL)
  • Clone: REA1026
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Entrez Gene ID: 21943
  • Distribution of antigen: dendritic cells, osteoblasts, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, VioBright 515, Biotin
  • Selected references

    1. Anderson, D. M. et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390(6656): 175-179
    2. Bekker, P. J. et al. (2004) A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J. Bone Miner. Res. 19(7): 1059-1066
    3. Luan, X. et al. (2012) Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin. J. Immunol. 189(1): 245-252
Product options: 10
30 µg in 200 µL (1)
EUR 80,00 
150 µg in 1 mL (1)
EUR 230,00 
30 µg in 200 µL (1)
EUR 80,00 
150 µg in 1 mL (1)
EUR 230,00 
30 µg in 200 µL (1)
EUR 100,00 
150 µg in 1 mL (1)
EUR 295,00 
30 µg in 200 µL (1)
EUR 145,00 
150 µg in 1 mL (1)
EUR 420,00 
30 µg in 200 µL (1)
EUR 40,00 
150 µg in 1 mL (1)
EUR 120,00 

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