CD252 (OX40L) antibodies – functional grade, rat

CD252 (OX40L) antibodies – functional grade, rat

Clone: ATM-2
Clone ATM-2 recognizes the rat CD252 antigen, a member of the TNF ligand superfamily, also known as OX40 ligand (OX40L) or tumor necrosis factor ligand superfamily member 4 (TNSFSF4). CD252 is constitutively expressed by splenic dendritic cells and can be upregulated on splenic B cells via stimulation with LPS. Expression of the cognate receptor CD134 (OX40) is found predominantly on activated T cells. CD252/CD134 interaction promotes the proliferation and survival of effector T cells, modulates cytokine production, suppresses the activity of natural regulatory T cells, and inhibits the generation of inducible regulatory T cells.

Applications

The CD252 (OX40L) pure – functional grade antibody is suited for functional assays, for example, blocking of receptor-ligand binding.

Alternative Names

TNFSF4, OX40L

Technical specifications

  • Antigen: CD252 (OX40L)
  • Clone: ATM-2
  • Isotype: mouse IgG1κ
  • Alternative names of antigen: TNFSF4, OX40L
  • Entrez Gene ID: 89814
  • Molecular mass of antigen [kDa]: 22
  • Distribution of antigen: B cells, dendritic cells, T cells, thymocytes
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected References

    1. Satake, Y. et al. (2000) Characterization of rat OX40 ligand by monoclonal antibody. Biochem. Biophys. Res. Commun. 270(3): 1041-1048
    2. Paterson, D. J. et al. (1987) Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. Mol. Immunol. 24(12): 1281-1290
    3. Ishii, N. et al. (2010) OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology. Adv. Immunol. 105: 63-98
Product options: 1

Product information

Size
Order no.
Price

CD252 (OX40L) pure - functional grade, rat

  • ATM-2
  • For research use only
500 µg in 0.5 mL
130-104-212
EUR 258,00