CD244 (2B4) antibodies, human

CD244 (2B4) antibodies, human

Clone: REA112
Clone REA112 recognizes CD244, a type I transmembrane receptor belonging to the CD2 subfamily of the Ig superfamily. Expression of CD244 is found on all natural killer (NK) cells, large subset of CD8
T cells, a small fraction of CD4
T cells, and eosinophils. Human CD244 upon ligand engagement activates NK cell cytotoxicity and production of interferon gamma (IFN-γ). Activating function of human CD244 requires recruitment of SH2 domain containing molecule called SLAM associated protein (SAP). In humans, CD244 has also been implicated as an inhibitory receptor such as in developing NK cells. In contrast, murine CD244 is primarily involved in inhibiting NK cell functions. Two isoforms of human CD244 exist on NK cells, h2B4-A and h2B4-B, which differ in their binding affinity to ligand CD48.
Additional information: Clone REA112 displays negligible binding to Fc receptors.

Alternative names

2B4, NAIL, NKR2B4, Nmrk, SLAMF4

Technical specifications

  • Antigen: CD244 (2B4)
  • Clone: REA112
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: 2B4, NAIL, NKR2B4, Nmrk, SLAMF4
  • Entrez Gene ID: 51744
  • Molecular mass of antigen [kDa]: 39
  • Distribution of antigen: NK cells, T cells, eosinophils
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
Product options: 1
100 µg in 100 µL
EUR 195,00