CD226 (DNAM-1) antibodies, human

CD226 (DNAM-1) antibodies, human

Clone: DX11 | Dilution: 1:11
Clone DX11 recognizes CD226 (DNAM-1), a 65 kDa transmembrane glycoprotein expressed on T cells, NK cells, platelets, monocytes, and a subset of B cells. It is also expressed by a subset of CD3
+
thymocytes. The surface association of CD226 (DNAM-1) with LFA-1 on NK cells and T cells permits the transduction of cytolytic signals upon binding of CD226 (DNAM-1) to its ligands CD155 (PVR) and CD112 (Nectin-2).

Alternative Names

DNAM-1, PTA-1, TLiSA1

Technical specifications

  • Antigen: CD226 (DNAM-1)
  • Clone: DX11
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: DNAM-1, PTA-1, TLiSA1
  • Entrez Gene ID: 10666
  • Molecular mass of antigen [kDa]: 37
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    ,
    olive baboon (
    Papio anubis
    )
  • Distribution of antigen: B cells, lymphocytes, monocytes, NK cells, platelets, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin, pure
  • Selected References

    1. Shibuya, A. et al. (1996) DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. Immunity 4: 573-581
    2. Bottino, C. et al. (2003) Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J. Exp. Med. 198: 557-567
    3. Moretta, L. and Moretta, A. (2004) Unravelling natural killer function: Triggering and inhibitory human NK receptors. EMBO J. 23: 255-259
    4. Kojima, H. et al. (2003) CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells. J. Biol. Chem. 278: 36748-36753
    5. Castriconi, R. et al. (2004) Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accesory molecule-1-poliovirus receptor interaction. Cancer Res. 64: 9180-9184
    6. Pende, D. et al. (2005) Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the poliovirus receptor (CD155) and Nectin-2 (CD112). Blood 105: 2066-2073
Product options: 9
130-100-461

CD226 (DNAM-1)-PE, human

for 30
tests
(1)
EUR 110,00 
130-092-476

CD226 (DNAM-1)-PE, human

for 100
tests
(1)
EUR 265,00 
130-100-436

CD226 (DNAM-1)-APC, human

for 30
tests
(1)
EUR 110,00 
130-092-477

CD226 (DNAM-1)-APC, human

for 100
tests
(1)
EUR 265,00 
130-099-961

CD226 (DNAM-1)-PE-Vio770, human

for 30
tests
(1)
EUR 120,00 
130-099-966

CD226 (DNAM-1)-PE-Vio770, human

for 100
tests
(1)
EUR 290,00 
130-100-437

CD226 (DNAM-1)-Biotin, human

for 30
tests
(1)
EUR 90,00 
130-092-478

CD226 (DNAM-1)-Biotin, human

for 100
tests
(1)
EUR 220,00 
130-092-479

CD226 (DNAM-1) pure, human

100 µg in 1 mL
EUR 198,00