CD22 antibodies, human

CD22 antibodies, human

Clone: REA340 | Dilution: 1:50
Clone REA340 recognizes the human CD22 antigen, a single-pass type I membrane protein which is also known as sialic acid-binding Ig-like lectin 2 (Siglec-2). In peripheral blood, cell surface expression of CD22 is found on mature B cells, but is lost during terminal differentiation to plasma cells. In bone marrow, surface expression of CD22 can be detected from the pre–B cell stage on. Cytoplasmic expression of CD22 can also be found in late pro–B cells and early–B cells. CD22 plays a strong role in cell interactions and B cell activation. It is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22 has emerged as an ideal target for monoclonal antibody based therapy of B cell malignancies including most lymphomas and many leukemias.
Additional information: Clone REA340 displays negligible binding to Fc receptors.

Alternative names

SIGLEC-2, B-lymphocyte cell adhesion molecule (BL-CAM), Sialic acid-binding Ig-like lectin 2 (Siglec-2), T cell surface antigen Leu-14

Technical specifications

  • Antigen: CD22
  • Clone: REA340
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SIGLEC-2, B-lymphocyte cell adhesion molecule (BL-CAM), Sialic acid-binding Ig-like lectin 2 (Siglec-2), T cell surface antigen Leu-14
  • Entrez Gene ID: 933
  • Molecular mass of antigen [kDa]: 93
  • Distribution of antigen: B cells, bone marrow
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE
  • Selected references

    1. Stamenkovic, I. et al. (1990) The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion. Nature 345(6270): 74-77
    2. Wilson, G. L. et al. (1991) cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions. J. Exp. Med. 173(1): 137-146
    3. Sullivan-Chang, L. et al. (2013) Targeting CD22 in B-cell malignancies: current status and clinical outlook. BioDrugs 27(4): 293-304
Product options: 4
130-120-830

CD22-APC, human

for 30
tests
(1)
EUR 110,00 
130-120-762

CD22-APC, human

for 100
tests
(1)
EUR 265,00 
130-123-306

CD22-PE, human

for 30
tests
(1)
EUR 110,00 
130-123-245

CD22-PE, human

for 100
tests
(1)
EUR 265,00 

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