CD22 antibodies, human

CD22 antibodies, human

Clone: REA340 | Dilution: 1:11
Clone REA340 recognizes the human CD22 antigen, a single-pass type I membrane protein which is also known as sialic acid-binding Ig-like lectin 2 (Siglec-2). In peripheral blood, cell surface expression of CD22 is found on mature B cells, but is lost during terminal differentiation to plasma cells. In bone marrow, surface expression of CD22 can be detected from the pre–B cell stage on. Cytoplasmic expression of CD22 can also be found in late pro–B cells and early–B cells. CD22 plays a strong role in cell interactions and B cell activation. It is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. CD22 has emerged as an ideal target for monoclonal antibody based therapy of B cell malignancies including most lymphomas and many leukemias.
Additional information: Clone REA340 displays negligible binding to Fc receptors.

Alternative Names

SIGLEC-2, B-lymphocyte cell adhesion molecule (BL-CAM), Sialic acid-binding Ig-like lectin 2 (Siglec-2), T cell surface antigen Leu-14

Technical specifications

  • Antigen: CD22
  • Clone: REA340
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: SIGLEC-2, B-lymphocyte cell adhesion molecule (BL-CAM), Sialic acid-binding Ig-like lectin 2 (Siglec-2), T cell surface antigen Leu-14
  • Entrez Gene ID: 933
  • Molecular mass of antigen [kDa]: 93
  • Distribution of antigen: B cells, bone marrow
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
Product options: 14

Product information

Size
Order no.
Price

CD22-FITC, human

  • REA340
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-087
EUR 74,00 

CD22-FITC, human

  • REA340
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-057
EUR 185,00 

CD22-PE, human

  • REA340
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-086
EUR 91,00 

CD22-PE, human

  • REA340
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-056
EUR 236,00 

CD22-VioBlue, human

  • REA340
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-088
EUR 91,00 

CD22-VioBlue, human

  • REA340
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-058
EUR 241,00 

CD22-PE-Vio770, human

  • REA340
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-089
EUR 113,00 

CD22-PE-Vio770, human

  • REA340
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-059
EUR 278,00 

CD22-APC-Vio770, human

  • REA340
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-090
EUR 101,00 

CD22-APC-Vio770, human

  • REA340
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-060
EUR 278,00 

CD22-PerCP-Vio700, human

  • REA340
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-091
EUR 113,00 

CD22-PerCP-Vio700, human

  • REA340
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-061
EUR 300,00 

CD22-Biotin, human

  • REA340
  • 1:11
  • For research use only
for 30
tests
(1)
130-105-084
EUR 74,00 

CD22-Biotin, human

  • REA340
  • 1:11
  • For research use only
for 100
tests
(1)
130-105-054
EUR 236,00 

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