CD209b (SIGN-R1) antibodies, mouse

CD209b (SIGN-R1) antibodies, mouse

Clone: REA125 | Dilution: 1:50
Clone REA125 recognizes the mouse CD209b antigen, a single-pass type II membrane protein also known as DC-SIGN-related protein 1 (SIGN-R1). CD209b was identified by examination of the mouse genome in search of the complete set of proteins related to the human glycan binding receptor CD209 (DC-SIGN). Unlike the human CD209, mouse CD209b is not expressed on dendritic cells (DCs) but is on splenic marginal zone, lymph node, and peritoneal macrophages. Its high affinity for murine ICAM-2, and its localization at sites that are in close contact with blood, suggest a role for CD209b in lymphocyte migration from the blood into tissues. Moreover, marginal zone macrophages in the spleen efficiently capture blood-borne antigens
in vivo
through CD209b. CD209b has also been shown to interact with the TLR signaling system, with CD209b associating with the TLR4-MD2 complex to enhance signal transduction in response to LPS in Gram-negative bacteria
in vitro
.
Additional information: Clone REA125 displays negligible binding to Fc receptors.

Alternative Names

DC-SIGNR1, OtB7, SIGNR1, mSIGNR1

Technical specifications

  • Antigen: CD209b (SIGN-R1)
  • Clone: REA125
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: DC-SIGNR1, OtB7, SIGNR1, mSIGNR1
  • Entrez Gene ID: 69165
  • Molecular mass of antigen [kDa]: 37
  • Distribution of antigen: macrophages, spleen, lymphocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC

Related products

3 products available
Product options: 2

Product information

Size
Order no.
Price

CD209b (SIGN-R1)-PE, mouse

  • REA125
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-117-786
EUR 57,00 

CD209b (SIGN-R1)-APC, mouse

  • REA125
  • 1:50
  • For research use only
30 µg in 200 µL (1)
130-117-499
EUR 83,00