CD209 (DC-SIGN) antibodies, human

CD209 (DC-SIGN) antibodies, human

Clone: REA617 | Dilution: 1:50
Clone REA617 recognizes the CD209 antigen, also known as dendritic cell specific ICAM-3 grabbing non-integrin (DC-SIGN), a type II c-type lectin expressed in dermal and mucous tissue, lymphoid tissue such as tonsil, lymph node, spleen, as well as on monocyte-derived DCs (MoDCs). It is not expressed on DC subsets in peripheral blood, except for a subpopulation of CD14
+
cells with a DC-like phenotype. DC-SIGN acts as an adhesion receptor to facilitate interactions between DCs and T cells or DCs and endothelial cells. In addition, it serves as an antigen receptor mediating internalization of ligands for antigen presentation, binding virus such as HIV, HCMV, or Ebola as well as parasites, bacteria, or yeast. HIV-1 uses this feature of DC-SIGN for efficient intrans infection of CD4
+
T cells.
Additional information: Clone REA617 displays negligible binding to Fc receptors.

Alternative Names

DC-SIGN, DC-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, DC-SIGN1

Technical specifications

  • Antigen: CD209 (DC-SIGN)
  • Clone: REA617
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: DC-SIGN, DC-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, DC-SIGN1
  • Entrez Gene ID: 30835
  • Molecular mass of antigen [kDa]: 46
  • Distribution of antigen: dendritic cells, endothelial cells, macrophages, skin, spleen
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE

Related products

4 products available
Product options: 4

Product information

Size
Order no.
Price

CD209 (DC-SIGN)-FITC, human

  • REA617
  • 1:50
  • For research use only
for 30
tests
(1)
130-119-822
EUR 65,00 

CD209 (DC-SIGN)-FITC, human

  • REA617
  • 1:50
  • For research use only
for 100
tests
(1)
130-119-784
EUR 234,00 

CD209 (DC-SIGN)-PE, human

  • REA617
  • 1:50
  • For research use only
for 30
tests
(1)
130-117-818
EUR 85,00 

CD209 (DC-SIGN)-PE, human

  • REA617
  • 1:50
  • For research use only
for 100
tests
(1)
130-117-706
EUR 276,00