CD1c (BDCA-1) antibodies, human

CD1c (BDCA-1) antibodies, human

Clone: REA694
Clone REA694 recognizes the human CD1c antigen, also known as BDCA-1. CD1c is expressed on a major subpopulation of human myeloid dendritic cells (about 0.3% of blood leukocytes). Blood CD1c (BDCA-1)
myeloid dendritic cells are CD11c
, CD123
, CD4
, Lin
, CD45RO
, CD2
, CD16
, CD141 (BDCA-3)
, CD303 (BDCA-2)
, and CD304 (BDCA-4/Neuropilin-1)
. They express myeloid markers (CD13, CD33) as well as Fc receptors (CD32, CD64, FcεRI) and are of monocytoid appearance. A minor proportion of CD1c (BDCA-1)
myeloid dendritic cells expresses CD14 and CD11b. In blood, CD1c (BDCA-1) is also expressed on a subpopulation of CD19
small resting B lymphocytes. CD1c (BDCA-1) expression has also been detected on cortical thymocytes, on Langerhans cells, and on CD1a
dendritic cells generated
ex vivo
from monocytes or hematopoietic precursor cells. CD1c (BDCA-1)
myeloid dendritic cells have been designated as type-1 myeloid dendritic cells (MDC1s). The CD1c antigen is a member of the CD1 family of proteins that are structurally related to MHC class I proteins and mediate the presentation of non-peptide antigens to T cells.
Additional information: Clone REA694 displays negligible binding to Fc receptors.

Alternative names

BDCA-1, CD1, R7, M241, T6, CD1a

Technical specifications

  • Antigen: CD1c (BDCA-1)
  • Clone: REA694
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: BDCA-1, CD1, R7, M241, T6, CD1a
  • Entrez Gene ID: 911
  • Molecular mass of antigen [kDa]: 36
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    cynomolgus monkey (
    Macaca fascicularis
  • Distribution of antigen: dendritic cells, B cells
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
Product options: 1
100 µg in 100 µL
EUR 170,00