CD197 (CCR7) antibodies, human

CD197 (CCR7) antibodies, human

Clone: REA546 | Dilution: 1:11
Clone REA546 recognizes the human CD197 antigen, which is also known as CCR7. CD197 is a chemokine receptor with a C-C motif that mediates homing of T cells to secondary lymphoid organs via high endothelial venules (HEV). For example, naive T cells migrate very efficiently through lymph nodes using the adhesion molecules L-selectin, CD62L, and CCR7. Ligands for CCR7, e.g. CCL19, are expressed by the HEV of secondary lymphoid organs, by parenchymal cells within T cell zones of lymph nodes, and by endothelial cells at the openings of lymphatic vessels within peripheral tissues. Expression of CCR7 and the CD45RA isoform distinguishes three subsets of T cells: naive T cells (CCR7
+
CD45RA
+
), central memory T cells (CCR7
+
CD45RA
), and effector memory T cells (CCR7
CD45RA
).
Additional information: Clone REA546 displays negligible binding to Fc receptors.

Alternative Names

CCR7, BLR-2, CC-CKR-7, CCR-7, Cdw197, CMKBR7, EBI-1

Technical specifications

  • Antigen: CD197 (CCR7)
  • Clone: REA546
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CCR7, BLR-2, CC-CKR-7, CCR-7, Cdw197, CMKBR7, EBI-1
  • Entrez Gene ID: 1236
  • Molecular mass of antigen [kDa]: 40
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    , baboon
  • Distribution of antigen: T cells, endothelial cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, PerCP-Vio700, Biotin

REAfinity clone is tested against different known clones, in a blocking experiment, to identify whether they recognize completely overlapping (++), partially overlapping (+), or completely different epitopes (-). In a blocking experiment, cells are incubated with an excess of purified unconjugated REAfinity clone followed by staining with conjugated form of the other known clones. 

Other clonesOverlap in epitope recognition with REA546
3D12++
G043H7++
150503++
FR11-11E8++
REA108++
Product options: 8

Product information

Size
Order no.
Price

CD197 (CCR7)-FITC, human

  • REA546
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-308
EUR 86,00 

CD197 (CCR7)-FITC, human

  • REA546
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-284
EUR 252,00 

CD197 (CCR7)-APC, human

  • REA546
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-310
EUR 146,00 

CD197 (CCR7)-APC, human

  • REA546
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-286
EUR 322,00 

CD197 (CCR7)-PerCP-Vio700, human

  • REA546
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-312
EUR 129,00 

CD197 (CCR7)-PerCP-Vio700, human

  • REA546
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-288
EUR 308,00 

CD197 (CCR7)-Biotin, human

  • REA546
  • 1:11
  • For research use only
for 30
tests
(1)
130-108-306
EUR 86,00 

CD197 (CCR7)-Biotin, human

  • REA546
  • 1:11
  • For research use only
for 100
tests
(1)
130-108-282
EUR 252,00 

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