CD192 (CCR2) antibodies, human

CD192 (CCR2) antibodies, human

Clone: REA624 | Dilution: 1:11
Clone REA624 recognizes the CD192 antigen, a G protein–linked seven transmembrane receptor, which is also known as C-C chemokine receptor type 2 (CCR2) or monocyte chemoattractant protein 1 receptor (MCP-1-R). Two spliced variants of CD192 (CD192A and CD192B) are expressed on peripheral monocytes and basophils as a result of alternate splicing of a single gene and differ at the C-terminal end. CD192 and its main ligand CCL2 have been implicated in a wide range of immunobiological processes and neuropathologies, including recruitment of monocytes and regulation of bone marrow homeostasis, as well as multiple sclerosis, HIV-associated dementia, Alzheimer’s disease, and neuropathic pain.
Additional information: Clone REA624 displays negligible binding to Fc receptors.

Alternative names

C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CCR-2, Monocyte chemoattractant protein 1 receptor, MCP-1-R, MCP-1R

Technical specifications

  • Antigen: CD192 (CCR2)
  • Clone: REA624
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CCR-2, Monocyte chemoattractant protein 1 receptor, MCP-1-R, MCP-1R
  • Entrez Gene ID: 1231
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: basophils, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Charo, I. F. et al. (1994) Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails. Proc. Natl. Acad. Sci. U.S.A. 91(7): 2752-2756
    2. Wong, L. M. et al. (1997) Organization and differential expression of the human monocyte chemoattractant protein 1 receptor gene. Evidence for the role of the carboxyl-terminal tail in receptor trafficking. J. Biol. Chem. 272(2): 1038-1045
    3. Henrich, T. J. et al. (2013) HIV-1 entry inhibitors: recent development and clinical use. Curr. Opin. Virol. 3(1): 51-57
Product options: 12
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 110,00 
for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 110,00 
for 100
tests
(1)
EUR 265,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 90,00 
for 100
tests
(1)
EUR 220,00 

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