CD181 (CXCR1) antibodies, human

CD181 (CXCR1) antibodies, human

Clone: REA958 | Dilution: 1:50
Clone REA958 recognizes the human CD181 antigen, a multi-pass membrane protein also known as C-X-C chemokine receptor type 1 (CXCR1) or IL-8 receptor A (IL-8RA). CD181 is expressed as homodimer or heterodimer with CD182 (CXCR2) and found on granulocytes, natural killer (NK) cells, a subset of T lymphocytes, mast cells, monocytes, endothelial cells, megakarocytes, and oligodendrocytes. It is one of two high-affinity receptors for interleukin 8 (IL-8), a major mediator of immune and inflammatory responses implicated in many disorders, including tumor growth. IL-8, released in response to inflammatory stimuli, binds to the extracellular part of CD181. The ligand-activated intracellular signaling pathways results in neutrophil migration to the site of inflammation.
Additional information: Clone REA958 displays negligible binding to Fc receptors.

Alternative names

CXCR1, C-C, C-C-CKR-1, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA

Technical specifications

  • Antigen: CD181 (CXCR1)
  • Clone: REA958
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CXCR1, C-C, C-C-CKR-1, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA
  • Entrez Gene ID: 3577
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: granulocytes, endothelial cells, lymphocytes, mast cells, megakaryocytes, monocytes, NK cells, oligodendrocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700
  • Selected references

    1. Holmes, W. E. et al. (1991) Structure and functional expression of a human interleukin-8 receptor. Science 253(5025): 1278
    2. Cummings, C. J. et al. (1999) Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis. J. Immunol. 162(4): 2341-2346
Product options: 17
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EUR 110,00 
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EUR 265,00 
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EUR 110,00 
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EUR 265,00 
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EUR 115,00 
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EUR 275,00 
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(1)
EUR 115,00 
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EUR 275,00 
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EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00 
for 100
tests
(1)
EUR 290,00 
for 30
tests
(1)
EUR 120,00 
for 100
tests
(1)
EUR 290,00